Transgenic rat models of vasopressin overexpression.

Yutaka Oiso, Hiroshi Nagasaki, Hisashi Yokoi

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Vasopressin has an important role in water metabolism and its impairment induces some clinical disorders such as diabetes insipidus or syndrome of inappropriate antidiuresis (SIAD). SIAD is caused by the overproduction of vasopressin which induces diluting hyponatremia. The accurate diagnosis and appropriate therapy have not settled up to date because its pathophysiology is very complicated. It is meaningful to develop a rat model of SIAD in which human vasopressin gene is overexpressed in order to analyze pathophysiological changes. Several models transgenic for vasopressin including us had been generated. The transgenic rats provide a useful model to investigate various pathophysiological changes resulting from the oversecretion of vasopressin. Some interesting results based on these animal models are reviewed.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalNagoya journal of medical science
Volume66
Issue number3-4
Publication statusPublished - 11-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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