Transient abnormal myelopoiesis in down's syndrome

Hiroki Kurahashi, Junichi Hara, Keiko Yumura-Yag, Akio Tawa, Keisei Kawa-Ha

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Recent data have elucidated the pathogenesis of transient abnormal myelopoiesis (TAM) to a great extent. TAM is a monoclonal disorder which resolves spontaneously and the target cell in this disorder is a multipotent stem cell which is capable of differentiating into megakaryocytes. The pathogeneses of TAM/AMKL (acute megakaryoblastic leukemia) appears to be closely associated with abnormal quality and quantity of a gene located on chromosome 21. AMKL developing after the regression of TAM appears to come from the same clone as the TAM, which apparently experiences some kind of genetic alterations. It seems that the gene responsible for TAM will soon be cloned in the near future. However, the mechanism of spontaneous regression of TAM has as yet not been clarified. The expanding clone in the transient phsysiological immunodeficient state, during the perinatal period, might be eliminated with the maturation of more mature immunosurveilance. Alternatively, the TAM clone might be destined to undergo spontaneous death, which is called "programmed cell death" (apoptosis). The mechanism of this phenomenon awaits further elucidation.

Original languageEnglish
Pages (from-to)465-475
Number of pages11
JournalLeukemia and Lymphoma
Volume8
Issue number6
DOIs
Publication statusPublished - 01-01-1992
Externally publishedYes

Fingerprint

Down Syndrome
Clone Cells
Leukemia, Megakaryoblastic, Acute
Multipotent Stem Cells
Chromosomes, Human, Pair 21
Megakaryocytes
Transient Myeloproliferative Syndrome
Genes
Cell Death
Apoptosis

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Kurahashi, Hiroki ; Hara, Junichi ; Yumura-Yag, Keiko ; Tawa, Akio ; Kawa-Ha, Keisei. / Transient abnormal myelopoiesis in down's syndrome. In: Leukemia and Lymphoma. 1992 ; Vol. 8, No. 6. pp. 465-475.
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Kurahashi, H, Hara, J, Yumura-Yag, K, Tawa, A & Kawa-Ha, K 1992, 'Transient abnormal myelopoiesis in down's syndrome', Leukemia and Lymphoma, vol. 8, no. 6, pp. 465-475. https://doi.org/10.3109/10428199209051029

Transient abnormal myelopoiesis in down's syndrome. / Kurahashi, Hiroki; Hara, Junichi; Yumura-Yag, Keiko; Tawa, Akio; Kawa-Ha, Keisei.

In: Leukemia and Lymphoma, Vol. 8, No. 6, 01.01.1992, p. 465-475.

Research output: Contribution to journalArticle

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