Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products

Haruo Mizuno, Yoichiro Ohro, Yukari Sugiyama, Tetsuya Ito, Tomonobu Hasegawa, Keiko Homma, Hajime Ueshiba, Makoto Ono, Hajime Togari

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Abstract

Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalHormone Research
Volume61
Issue number5
DOIs
Publication statusPublished - 27-04-2004
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Mizuno, H., Ohro, Y., Sugiyama, Y., Ito, T., Hasegawa, T., Homma, K., Ueshiba, H., Ono, M., & Togari, H. (2004). Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products. Hormone Research, 61(5), 242-245. https://doi.org/10.1159/000076961