Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products

Haruo Mizuno, Yoichiro Ohro, Yukari Sugiyama, Tetsuya Ito, Tomonobu Hasegawa, Keiko Homma, Hajime Ueshiba, Makoto Ono, Hajime Togari

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalHormone Research
Volume61
Issue number5
DOIs
Publication statusPublished - 27-04-2004
Externally publishedYes

Fingerprint

Adrenal Cortex
Cross Reactions
Steroid 21-Hydroxylase
Serum
17-alpha-Hydroxyprogesterone
Genes
Radioimmunoassay
Steroids
High Pressure Liquid Chromatography
Mutation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Mizuno, Haruo ; Ohro, Yoichiro ; Sugiyama, Yukari ; Ito, Tetsuya ; Hasegawa, Tomonobu ; Homma, Keiko ; Ueshiba, Hajime ; Ono, Makoto ; Togari, Hajime. / Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products. In: Hormone Research. 2004 ; Vol. 61, No. 5. pp. 242-245.
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abstract = "Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.",
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Mizuno, H, Ohro, Y, Sugiyama, Y, Ito, T, Hasegawa, T, Homma, K, Ueshiba, H, Ono, M & Togari, H 2004, 'Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products', Hormone Research, vol. 61, no. 5, pp. 242-245. https://doi.org/10.1159/000076961

Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products. / Mizuno, Haruo; Ohro, Yoichiro; Sugiyama, Yukari; Ito, Tetsuya; Hasegawa, Tomonobu; Homma, Keiko; Ueshiba, Hajime; Ono, Makoto; Togari, Hajime.

In: Hormone Research, Vol. 61, No. 5, 27.04.2004, p. 242-245.

Research output: Contribution to journalArticle

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T1 - Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products

AU - Mizuno, Haruo

AU - Ohro, Yoichiro

AU - Sugiyama, Yukari

AU - Ito, Tetsuya

AU - Hasegawa, Tomonobu

AU - Homma, Keiko

AU - Ueshiba, Hajime

AU - Ono, Makoto

AU - Togari, Hajime

PY - 2004/4/27

Y1 - 2004/4/27

N2 - Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.

AB - Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.

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