Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products

Haruo Mizuno; Yoichiro Ohro; Yukari Sugiyama; Tetsuya Ito; Tomonobu Hasegawa; Keiko Homma; Hajime Ueshiba; Makoto Ono; Hajime Togari

doi:10.1159/000076961

Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products

Haruo Mizuno, Yoichiro Ohro, Yukari Sugiyama, Tetsuya Ito, Tomonobu Hasegawa, Keiko Homma, Hajime Ueshiba, Makoto Ono, Hajime Togari

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.

Original language	English
Pages (from-to)	242-245
Number of pages	4
Journal	Hormone Research
Volume	61
Issue number	5
DOIs	https://doi.org/10.1159/000076961
Publication status	Published - 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000076961

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title = "Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products",

abstract = "Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.",

keywords = "21-Hydroxylase, Gas chromatography-mass spectrometry, High-performance liquid chromatography-radioimmunoassay, Hyper-17α-hydroxyprogesteronemia, Transient hyper-17-OHPnemia",

author = "Haruo Mizuno and Yoichiro Ohro and Yukari Sugiyama and Tetsuya Ito and Tomonobu Hasegawa and Keiko Homma and Hajime Ueshiba and Makoto Ono and Hajime Togari",

year = "2004",

doi = "10.1159/000076961",

language = "English",

volume = "61",

pages = "242--245",

journal = "Hormone Research",

issn = "0301-0163",

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}

TY - JOUR

T1 - Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products

AU - Mizuno, Haruo

AU - Ohro, Yoichiro

AU - Sugiyama, Yukari

AU - Ito, Tetsuya

AU - Hasegawa, Tomonobu

AU - Homma, Keiko

AU - Ueshiba, Hajime

AU - Ono, Makoto

AU - Togari, Hajime

PY - 2004

Y1 - 2004

N2 - Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.

AB - Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.

KW - 21-Hydroxylase

KW - Gas chromatography-mass spectrometry

KW - High-performance liquid chromatography-radioimmunoassay

KW - Hyper-17α-hydroxyprogesteronemia

KW - Transient hyper-17-OHPnemia

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JO - Hormone Research

JF - Hormone Research

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Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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