Translational Research Using Carbohydrate Mimetic Peptides

Michiko N. Fukuda, Kazuhiro Sugihara

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In the era of translational research, carbohydrate-based drug discovery has yet to be explored. This is due in large part to our inability to undertake automated chemical synthesis of complex carbohydrates. This dilemma can be partially, if not totally, circumvented by using carbohydrate mimetic peptides, which can be identified from peptide-displaying phage library. In this approach, a phage clone displaying a short peptide that mimics part of the conformation of specific carbohydrate structure is selected by screening a peptide-displaying phage library using anti-carbohydrate antibody or lectin as target. Chemically synthesized peptides function as ligands for carbohydrate-binding proteins in vitro and in vivo. Peptides can also serve as immunogens to raise anti-carbohydrate antibodies in vivo in animals. This chapter provides examples of successful application of peptide-displaying phage technology to drug discovery. These approaches should benefit translational research by supplying carbohydrate mimetic peptides as diagnostics and therapeutics.

Original languageEnglish
Title of host publicationGlycoscience
Subtitle of host publicationBiology and Medicine
PublisherSpringer Japan
Pages1523-1528
Number of pages6
ISBN (Electronic)9784431548416
ISBN (Print)9784431548409
DOIs
Publication statusPublished - 01-01-2015

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Fukuda, M. N., & Sugihara, K. (2015). Translational Research Using Carbohydrate Mimetic Peptides. In Glycoscience: Biology and Medicine (pp. 1523-1528). Springer Japan. https://doi.org/10.1007/978-4-431-54841-6_202