Translesion synthesis: Y-family polymerases and the polymerase switch

Alan R. Lehmann, Atsuko Niimi, Tomoo Ogi, Stephanie Brown, Simone Sabbioneda, Jonathan F. Wing, Patricia L. Kannouche, Catherine M. Green

Research output: Contribution to journalArticle

294 Citations (Scopus)

Abstract

Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks.

Original languageEnglish
Pages (from-to)891-899
Number of pages9
JournalDNA Repair
Volume6
Issue number7
DOIs
Publication statusPublished - 01-07-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Lehmann, A. R., Niimi, A., Ogi, T., Brown, S., Sabbioneda, S., Wing, J. F., Kannouche, P. L., & Green, C. M. (2007). Translesion synthesis: Y-family polymerases and the polymerase switch. DNA Repair, 6(7), 891-899. https://doi.org/10.1016/j.dnarep.2007.02.003