Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population

Akiko Okuda, T. Kishi, Tomo Okochi, Masashi Ikeda, Tsuyoshi Kitajima, Tomoko Tsunoka, Takenori Okumukura, Yasuhisa Fukuo, Yoko Kinoshita, Kunihiro Kawashima, Yoshio Yamanouchi, Toshiya Inada, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-inschizophrenia-1 gene (DISCI) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). TSNAX is located immediately upstream of DISC1, and has been shown to undergo intergenic splicing with DISC1. It thus may also be influenced by translocation. To our knowledge, there are no reported gene-based association analyses between TSNAX and mood disorders in the Japanese population. We conducted a case-control study of Japanese samples (158 bipolar patients, 314 major depressive disorder patients, and 811 controls) with three tagging SNPs in TSNAX, selected using HapMap database. In addition, we performed an association analysis between TSNAX and the efficacy of fluvoxamine treatment in 120 Japanese patients with MDD. The MDD patients in this study had scores of 12 or higher on the 17 items of the Structured Interview Guide for Hamilton Rating Scale for Depression (SIGH-D). We defined a clinical response as a decrease of more than 50% in baseline SIGH-D within 8 weeks, and clinical remission as an SIGH-D score of less than 7 at 8 weeks. We found an association between rs766288 in TSNAX and female MDD in the allele/genotype analysis. However, we did not find any association between TSNAX and BP or the fluvoxamine therapeutic response in MDD in the allele/genotype analysis or haplotype analysis. Our results suggest that rs766288 in TSNAX may play a role in the pathophysiology of female MDD in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalNeuroMolecular Medicine
Volume12
Issue number1
DOIs
Publication statusPublished - 01-03-2010

Fingerprint

Factor X
Major Depressive Disorder
Population
Genes
Fluvoxamine
Bipolar Disorder
Alleles
Genotype
HapMap Project
Mood Disorders
Sample Size
Haplotypes
Single Nucleotide Polymorphism
Psychiatry
Case-Control Studies
Schizophrenia
Databases
Interviews
Depression

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Okuda, Akiko ; Kishi, T. ; Okochi, Tomo ; Ikeda, Masashi ; Kitajima, Tsuyoshi ; Tsunoka, Tomoko ; Okumukura, Takenori ; Fukuo, Yasuhisa ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Yamanouchi, Yoshio ; Inada, Toshiya ; Ozaki, Norio ; Iwata, Nakao. / Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. In: NeuroMolecular Medicine. 2010 ; Vol. 12, No. 1. pp. 78-85.
@article{b2f209ce56f54cacae7edd9e6d8a7686,
title = "Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population",
abstract = "Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-inschizophrenia-1 gene (DISCI) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). TSNAX is located immediately upstream of DISC1, and has been shown to undergo intergenic splicing with DISC1. It thus may also be influenced by translocation. To our knowledge, there are no reported gene-based association analyses between TSNAX and mood disorders in the Japanese population. We conducted a case-control study of Japanese samples (158 bipolar patients, 314 major depressive disorder patients, and 811 controls) with three tagging SNPs in TSNAX, selected using HapMap database. In addition, we performed an association analysis between TSNAX and the efficacy of fluvoxamine treatment in 120 Japanese patients with MDD. The MDD patients in this study had scores of 12 or higher on the 17 items of the Structured Interview Guide for Hamilton Rating Scale for Depression (SIGH-D). We defined a clinical response as a decrease of more than 50{\%} in baseline SIGH-D within 8 weeks, and clinical remission as an SIGH-D score of less than 7 at 8 weeks. We found an association between rs766288 in TSNAX and female MDD in the allele/genotype analysis. However, we did not find any association between TSNAX and BP or the fluvoxamine therapeutic response in MDD in the allele/genotype analysis or haplotype analysis. Our results suggest that rs766288 in TSNAX may play a role in the pathophysiology of female MDD in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small.",
author = "Akiko Okuda and T. Kishi and Tomo Okochi and Masashi Ikeda and Tsuyoshi Kitajima and Tomoko Tsunoka and Takenori Okumukura and Yasuhisa Fukuo and Yoko Kinoshita and Kunihiro Kawashima and Yoshio Yamanouchi and Toshiya Inada and Norio Ozaki and Nakao Iwata",
year = "2010",
month = "3",
day = "1",
doi = "10.1007/s12017-009-8090-1",
language = "English",
volume = "12",
pages = "78--85",
journal = "NeuroMolecular Medicine",
issn = "1535-1084",
publisher = "Humana Press",
number = "1",

}

Okuda, A, Kishi, T, Okochi, T, Ikeda, M, Kitajima, T, Tsunoka, T, Okumukura, T, Fukuo, Y, Kinoshita, Y, Kawashima, K, Yamanouchi, Y, Inada, T, Ozaki, N & Iwata, N 2010, 'Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population', NeuroMolecular Medicine, vol. 12, no. 1, pp. 78-85. https://doi.org/10.1007/s12017-009-8090-1

Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. / Okuda, Akiko; Kishi, T.; Okochi, Tomo; Ikeda, Masashi; Kitajima, Tsuyoshi; Tsunoka, Tomoko; Okumukura, Takenori; Fukuo, Yasuhisa; Kinoshita, Yoko; Kawashima, Kunihiro; Yamanouchi, Yoshio; Inada, Toshiya; Ozaki, Norio; Iwata, Nakao.

In: NeuroMolecular Medicine, Vol. 12, No. 1, 01.03.2010, p. 78-85.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population

AU - Okuda, Akiko

AU - Kishi, T.

AU - Okochi, Tomo

AU - Ikeda, Masashi

AU - Kitajima, Tsuyoshi

AU - Tsunoka, Tomoko

AU - Okumukura, Takenori

AU - Fukuo, Yasuhisa

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Yamanouchi, Yoshio

AU - Inada, Toshiya

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-inschizophrenia-1 gene (DISCI) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). TSNAX is located immediately upstream of DISC1, and has been shown to undergo intergenic splicing with DISC1. It thus may also be influenced by translocation. To our knowledge, there are no reported gene-based association analyses between TSNAX and mood disorders in the Japanese population. We conducted a case-control study of Japanese samples (158 bipolar patients, 314 major depressive disorder patients, and 811 controls) with three tagging SNPs in TSNAX, selected using HapMap database. In addition, we performed an association analysis between TSNAX and the efficacy of fluvoxamine treatment in 120 Japanese patients with MDD. The MDD patients in this study had scores of 12 or higher on the 17 items of the Structured Interview Guide for Hamilton Rating Scale for Depression (SIGH-D). We defined a clinical response as a decrease of more than 50% in baseline SIGH-D within 8 weeks, and clinical remission as an SIGH-D score of less than 7 at 8 weeks. We found an association between rs766288 in TSNAX and female MDD in the allele/genotype analysis. However, we did not find any association between TSNAX and BP or the fluvoxamine therapeutic response in MDD in the allele/genotype analysis or haplotype analysis. Our results suggest that rs766288 in TSNAX may play a role in the pathophysiology of female MDD in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small.

AB - Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-inschizophrenia-1 gene (DISCI) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). TSNAX is located immediately upstream of DISC1, and has been shown to undergo intergenic splicing with DISC1. It thus may also be influenced by translocation. To our knowledge, there are no reported gene-based association analyses between TSNAX and mood disorders in the Japanese population. We conducted a case-control study of Japanese samples (158 bipolar patients, 314 major depressive disorder patients, and 811 controls) with three tagging SNPs in TSNAX, selected using HapMap database. In addition, we performed an association analysis between TSNAX and the efficacy of fluvoxamine treatment in 120 Japanese patients with MDD. The MDD patients in this study had scores of 12 or higher on the 17 items of the Structured Interview Guide for Hamilton Rating Scale for Depression (SIGH-D). We defined a clinical response as a decrease of more than 50% in baseline SIGH-D within 8 weeks, and clinical remission as an SIGH-D score of less than 7 at 8 weeks. We found an association between rs766288 in TSNAX and female MDD in the allele/genotype analysis. However, we did not find any association between TSNAX and BP or the fluvoxamine therapeutic response in MDD in the allele/genotype analysis or haplotype analysis. Our results suggest that rs766288 in TSNAX may play a role in the pathophysiology of female MDD in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small.

UR - http://www.scopus.com/inward/record.url?scp=77952506059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952506059&partnerID=8YFLogxK

U2 - 10.1007/s12017-009-8090-1

DO - 10.1007/s12017-009-8090-1

M3 - Article

C2 - 19760522

AN - SCOPUS:77952506059

VL - 12

SP - 78

EP - 85

JO - NeuroMolecular Medicine

JF - NeuroMolecular Medicine

SN - 1535-1084

IS - 1

ER -