TY - JOUR
T1 - Transplantation of neural stem cells into the spinal cord after injury
AU - Okano, Hideyuki
AU - Ogawa, Yuto
AU - Nakamura, Masaya
AU - Kaneko, Shinjiro
AU - Iwanami, Akio
AU - Toyama, Yoshiaki
N1 - Funding Information:
We thank Dr. Barbara Bregman for her invaluable discussions and suggestions and Kumiko Inoue and Akiyo Hirayama for their help in preparing the manuscript and excellent administrative assistance. Work in the author’s laboratory was supported by grants from the Japanese Ministry of Education, Culture, Sports, Science and Technology, and from the Japan Science and Technology Corporation (CREST).
PY - 2003/6
Y1 - 2003/6
N2 - Thanks to advances in the stem cell biology of the central nervous system (CNS), the previously inconceivable regeneration of the damaged CNS is approaching reality. The availability of signals to induce the appropriate differentiation of the transplanted and/or endogenous neural stem cells (NSCs) as well as the timing of the transplantation are important for successful functional recovery of the damaged CNS. Because the immediately post-traumatic microenvironment of the spinal cord is in an acute inflammatory stage, it is not favorable for the survival and differentiation of NSC transplants. On the other hand, in the chronic stage after injury, glial scars form in the injured site that inhibit the regeneration of neuronal axons. Thus, we believe that the optimal timing of transplantation is 1-2 weeks after injury.
AB - Thanks to advances in the stem cell biology of the central nervous system (CNS), the previously inconceivable regeneration of the damaged CNS is approaching reality. The availability of signals to induce the appropriate differentiation of the transplanted and/or endogenous neural stem cells (NSCs) as well as the timing of the transplantation are important for successful functional recovery of the damaged CNS. Because the immediately post-traumatic microenvironment of the spinal cord is in an acute inflammatory stage, it is not favorable for the survival and differentiation of NSC transplants. On the other hand, in the chronic stage after injury, glial scars form in the injured site that inhibit the regeneration of neuronal axons. Thus, we believe that the optimal timing of transplantation is 1-2 weeks after injury.
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U2 - 10.1016/S1084-9521(03)00011-9
DO - 10.1016/S1084-9521(03)00011-9
M3 - Article
C2 - 12948354
AN - SCOPUS:0742305014
SN - 1084-9521
VL - 14
SP - 191
EP - 198
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
IS - 3
ER -