Treatment of aplastic anemia with antilymphocyte globulin, high-dose methylprednisolone and androgen

S. Kojima, Y. Miyajima, M. Fukuda, T. Matsuyama, H. Maeda, K. Yamamoto, S. Tsuzuki, Yoshiki Akatsuka, T. Sugihara, S. Minami

Research output: Contribution to journalArticle

Abstract

Twenty-seven patients with aplastic anemia (20 severe: 7 moderate) were treated with combined immunosuppression consisting of antilymphocyte globulin (ALG: Ahlbulin, Green Cross Co., Osaka, Japan) and high-dose methylprednisolone. Danazol or meptiostane was administered concurrently for at least 3 months. Ten of 27 patients had sustained improvement in hematopoiesis within 3 months of treatment. Three patients with hematological response had a recurrence of pancytopenia 12-36 months after the combined immunosuppressive therapy. Six patients died due to fungal pneumonia (2), hepatic failure (2), interstitial pneumonitis (1) and complication following allogeneic bone marrow transplantation (1). By life table analysis, the survival rate for all patients was 76 +/- 8% at 4 years, with 70 +/- 10% survival rate for patients with severe aplastic anemia and 100% for patients with moderate aplastic anemia. The factors predicting the good response to the therapy were a longer interval from diagnosis to the therapy and higher counts of platelet and reticulocyte at admission.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume33
Issue number1
Publication statusPublished - 01-01-1992
Externally publishedYes

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Antilymphocyte Serum
Aplastic Anemia
Methylprednisolone
Androgens
Therapeutics
Survival Rate
Danazol
Reticulocyte Count
Pancytopenia
Life Tables
Interstitial Lung Diseases
Homologous Transplantation
Hematopoiesis
Liver Failure
Immunosuppressive Agents
Bone Marrow Transplantation
Platelet Count
Immunosuppression
Pneumonia
Japan

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kojima, S., Miyajima, Y., Fukuda, M., Matsuyama, T., Maeda, H., Yamamoto, K., ... Minami, S. (1992). Treatment of aplastic anemia with antilymphocyte globulin, high-dose methylprednisolone and androgen. [Rinshō ketsueki] The Japanese journal of clinical hematology, 33(1), 11-16.
Kojima, S. ; Miyajima, Y. ; Fukuda, M. ; Matsuyama, T. ; Maeda, H. ; Yamamoto, K. ; Tsuzuki, S. ; Akatsuka, Yoshiki ; Sugihara, T. ; Minami, S. / Treatment of aplastic anemia with antilymphocyte globulin, high-dose methylprednisolone and androgen. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 1992 ; Vol. 33, No. 1. pp. 11-16.
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Kojima, S, Miyajima, Y, Fukuda, M, Matsuyama, T, Maeda, H, Yamamoto, K, Tsuzuki, S, Akatsuka, Y, Sugihara, T & Minami, S 1992, 'Treatment of aplastic anemia with antilymphocyte globulin, high-dose methylprednisolone and androgen', [Rinshō ketsueki] The Japanese journal of clinical hematology, vol. 33, no. 1, pp. 11-16.

Treatment of aplastic anemia with antilymphocyte globulin, high-dose methylprednisolone and androgen. / Kojima, S.; Miyajima, Y.; Fukuda, M.; Matsuyama, T.; Maeda, H.; Yamamoto, K.; Tsuzuki, S.; Akatsuka, Yoshiki; Sugihara, T.; Minami, S.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 33, No. 1, 01.01.1992, p. 11-16.

Research output: Contribution to journalArticle

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T1 - Treatment of aplastic anemia with antilymphocyte globulin, high-dose methylprednisolone and androgen

AU - Kojima, S.

AU - Miyajima, Y.

AU - Fukuda, M.

AU - Matsuyama, T.

AU - Maeda, H.

AU - Yamamoto, K.

AU - Tsuzuki, S.

AU - Akatsuka, Yoshiki

AU - Sugihara, T.

AU - Minami, S.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Twenty-seven patients with aplastic anemia (20 severe: 7 moderate) were treated with combined immunosuppression consisting of antilymphocyte globulin (ALG: Ahlbulin, Green Cross Co., Osaka, Japan) and high-dose methylprednisolone. Danazol or meptiostane was administered concurrently for at least 3 months. Ten of 27 patients had sustained improvement in hematopoiesis within 3 months of treatment. Three patients with hematological response had a recurrence of pancytopenia 12-36 months after the combined immunosuppressive therapy. Six patients died due to fungal pneumonia (2), hepatic failure (2), interstitial pneumonitis (1) and complication following allogeneic bone marrow transplantation (1). By life table analysis, the survival rate for all patients was 76 +/- 8% at 4 years, with 70 +/- 10% survival rate for patients with severe aplastic anemia and 100% for patients with moderate aplastic anemia. The factors predicting the good response to the therapy were a longer interval from diagnosis to the therapy and higher counts of platelet and reticulocyte at admission.

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