TY - JOUR
T1 - Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation
AU - Kobayashi, Naoya
AU - Ito, Masahiro
AU - Nakamura, Junta
AU - Cai, Jin
AU - Hammel, James M.
AU - Fox, Ira J.
PY - 2000
Y1 - 2000
N2 - Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl4). Intrasplenic transplantation of 50 x 106 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.
AB - Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl4). Intrasplenic transplantation of 50 x 106 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.
UR - http://www.scopus.com/inward/record.url?scp=0034529733&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034529733&partnerID=8YFLogxK
U2 - 10.1177/096368970000900512
DO - 10.1177/096368970000900512
M3 - Article
C2 - 11144963
AN - SCOPUS:0034529733
SN - 0963-6897
VL - 9
SP - 671
EP - 673
JO - Cell Transplantation
JF - Cell Transplantation
IS - 5
ER -