Treatment of patients with unresectable advanced carcinoma of biliary tract - Chemotherapy and surgical resection

Zenichi Morise, Atsushi Sugioka, Yoshinao Tanahashi, Yasuhiro Okabe, Masahiro Ikeda, Tadashi Kagawa, Chinatsu Takeura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background: The results of 12 consecutive patients with unresectable advanced biliary tract carcinoma treated with first line chemotherapy of S1/cisplatin, combined surgical resection and second line chemotherapy of gemcitabine are evaluated. Patients and Methods: Eight patients with intrahepatic cholangiocarcinoma, 1 with extrahepatic cholangiocarcinoma and 3 with gallbladder carcinoma were included in the study. All patients were treated with S1/cisplatin. Two of the patients underwent combined surgical resection before and 2 after therapy. Second line chemotherapy of gemcitabine was administerd in 6 patients. Results: MST of the patients was 14.9 months. With S1/cisplatin therapy, 6 patients had PR and 4 had SD. Two patients with surgical resection after the therapy survived more than 3 years. Second line chemotherapy of gemcitabine with moderate effects and mild adverse effects was well tolerable. Conclusion: S1/cisplatin showed considerable anti-cancerous effects. Employing surgical resection for patients with good response may lead to the chance of long-term survival.

Original languageEnglish
Pages (from-to)1783-1786
Number of pages4
JournalAnticancer research
Volume29
Issue number5
Publication statusPublished - 01-05-2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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