Treatment of solid tumor by a small amount of direct current

K. Ito, Chung Lin Ye Chung Lin, K. Kondou, S. Akiyama, H. Takagi, H. Hirota, T. Endo, G. Itoh, M. Suzuki, S. Ikeda

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Solid tumor treatment was given in our animal laboratory to determine the mechanism of tumor disappearance by direct electric current, and clinical trials were done on 9 far advanced recurrent rectal cancers. Solid tumors of Yoshida sarcoma in Donryu rat were treated by 1 mA of constant direct current for 1 hour a day, for 4 days. The tumors disappeared in 13/16 within 21 days. Positive results of DNA Nick end labeling and ladder patterns in the gel electrophoresis of DNA were observed in the regressing tumor specimen. It is considered that apoptosis is the one of the mechanisms of a disappearing tumor. As for the clinical trial concern, in 9 cases of rectal cancer, one CR and 5 PR were seen.

Original languageEnglish
Pages (from-to)1647-1651
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Issue number11
Publication statusPublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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