Treatment outcome in nine cases of anal squamous cell carcinoma

Harunobu Sato, Yoshikazu Koide, Miho Shiota, Shinji Matsuoka, Kouhei Hatta, Masahiro Mizuno, Koutarou Maeda

Research output: Contribution to journalArticlepeer-review

Abstract

We reviewed the clinical records of 9 patients with anal squamous cell carcinoma (SCC) chiefly to evaluate the effectiveness of chemoradiotherapy (CRT). Surgery was performed in 1 patient; radiotherapy (RT), in 2; and CRT, in 6. RT consisted of 40 Gy delivered to the pelvic and bilateral inguinal lesions, and a perianal booster dose of 20 Gy in fractions of 2.0 Gy/day, 5 days a week. 5-fluorouracil (750 mg/m2, administered through a 24-h continuous infusion for 5 days) and mitomycin C (10 mg/m", administered as a single bolus infusion) were administered 3 times every 4 weeks as standard chemotherapy. One patient with a T3 tumor received oral TS-1 during RT because of advanced age. In the CRT group, 1 patient had a T1 tumor, another had a T3 tumor, and the others had a T2 tumor. Grade 2 adverse effects occurred in 3 patients, and grade 3 adverse effects occurred in 1 patient. Nevertheless, CRT was completed in all of the 6 patients. All the patients had complete response after CRT for the anal lesion. Two patients, one of whom had a T3 tumor treated with oral S-1, had recurrence of the anal lesion. The 2 patients (T2 and T3) who underwent RT and needed surgery because of residual tumor died of recurrent disease. The patient with a T4 tumor who underwent abdominoperineal resection also died of recurrent disease. CRT is considered a safe and effective treatment option to improve prognosis in anal SCC.

Original languageEnglish
Pages (from-to)1852-1854
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume41
Issue number12
Publication statusPublished - 11-2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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