Abstract
In this article, Okano and colleagues show that the GSI-treated hiPSC-NS/PCs caused significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. These favorable outcomes contributed to motor function improvement. Therefore, treating cells with GSI provides a beneficial effect after transplantation, even in the chronic phase following SCI.
Original language | English |
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Pages (from-to) | 1416-1432 |
Number of pages | 17 |
Journal | Stem Cell Reports |
Volume | 11 |
Issue number | 6 |
DOIs | |
Publication status | Published - 11-12-2018 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Genetics
- Developmental Biology
- Cell Biology