Treatment with cytapheresis for antineutrophil cytoplasmic antibody-associated renal vasculitis and its effect on anti-inflammatory factors

Midori Hasegawa, Asako Watanabe, Hiroki Takahashi, Kazuo Takahashi, Masami Kasugai, Nahoko Kawamura, Hiroko Kushimoto, Kazutaka Murakami, Makoto Tomita, Kunihiro Nabeshima, Atsushi Oohashi, Fumiko Kondou, Hisaji Ooshima, Yoshiyuki Hiki, Satoshi Sugiyama

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To evaluate the efficacy of cytapheresis for the treatment of rapidly progressive glomerulonephritis (RPGN) caused by myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis, the renal prognosis and the mortality rate at 1 year after treatment were compared between a Cytapheresis Group and a Steroid Pulse Group. The Cytapheresis Group included 10 patients who were treated with cytapheresis and oral corticosteroids. Five had granulocytapheresis with the Adacolumn (Japan Immuno Research Laboratories Co. Ltd, Takasaki, Japan) and the remaining five had leukocytapheresis with the leukocyte removal filter, Cellsorba (Asahi Medical Co. Ltd, Tokyo, Japan). The Steroid Pulse Group was comprised of 12 patients who were treated with methylprednisolone pulse therapy and oral corticosteroids. In the Cytapheresis Group, renal function recovered in 70% of the patients and the mortality rate was 10%. In the Steroid Pulse Group, renal function recovered in 66.7% and the mortality rate was 33.3%, with infection as the cause of death. Total doses of corticosteroids converted to prednisolone dose during a 1 month period, ranged from 280 mg to 1226 mg in the Cytapheresis Group. On the other hand, these dosages ranged from 2375 mg to 8380 mg in the Steroid Pulse Group. These results indicated that the mortality rate by infection could be reduced by adding cytapheresis therapy. Concerning the mechanism of cytapheresis, anti-inflammatory factors such as soluble tumor necrosis factor receptor, and interleukin-10 reduced after cytapheresis. These changes might be responsible for the efficacy of cytapheresis. In conclusion, cytapheresis is thought to be one of the effective treatments for RPGN caused by MPO-ANCA-associated vasculitis, reducing the levels of anti-inflammatory factors.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalTherapeutic Apheresis and Dialysis
Volume9
Issue number4
DOIs
Publication statusPublished - 01-01-2005

Fingerprint

Cytapheresis
Antineutrophil Cytoplasmic Antibodies
Vasculitis
Anti-Inflammatory Agents
Kidney
Steroids
Therapeutics
Japan
Adrenal Cortex Hormones
Mortality
Glomerulonephritis
Peroxidase
Leukapheresis
Tokyo
Tumor Necrosis Factor Receptors
Methylprednisolone
Prednisolone
Infection
Interleukin-10

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Hasegawa, Midori ; Watanabe, Asako ; Takahashi, Hiroki ; Takahashi, Kazuo ; Kasugai, Masami ; Kawamura, Nahoko ; Kushimoto, Hiroko ; Murakami, Kazutaka ; Tomita, Makoto ; Nabeshima, Kunihiro ; Oohashi, Atsushi ; Kondou, Fumiko ; Ooshima, Hisaji ; Hiki, Yoshiyuki ; Sugiyama, Satoshi. / Treatment with cytapheresis for antineutrophil cytoplasmic antibody-associated renal vasculitis and its effect on anti-inflammatory factors. In: Therapeutic Apheresis and Dialysis. 2005 ; Vol. 9, No. 4. pp. 297-302.
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abstract = "To evaluate the efficacy of cytapheresis for the treatment of rapidly progressive glomerulonephritis (RPGN) caused by myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis, the renal prognosis and the mortality rate at 1 year after treatment were compared between a Cytapheresis Group and a Steroid Pulse Group. The Cytapheresis Group included 10 patients who were treated with cytapheresis and oral corticosteroids. Five had granulocytapheresis with the Adacolumn (Japan Immuno Research Laboratories Co. Ltd, Takasaki, Japan) and the remaining five had leukocytapheresis with the leukocyte removal filter, Cellsorba (Asahi Medical Co. Ltd, Tokyo, Japan). The Steroid Pulse Group was comprised of 12 patients who were treated with methylprednisolone pulse therapy and oral corticosteroids. In the Cytapheresis Group, renal function recovered in 70{\%} of the patients and the mortality rate was 10{\%}. In the Steroid Pulse Group, renal function recovered in 66.7{\%} and the mortality rate was 33.3{\%}, with infection as the cause of death. Total doses of corticosteroids converted to prednisolone dose during a 1 month period, ranged from 280 mg to 1226 mg in the Cytapheresis Group. On the other hand, these dosages ranged from 2375 mg to 8380 mg in the Steroid Pulse Group. These results indicated that the mortality rate by infection could be reduced by adding cytapheresis therapy. Concerning the mechanism of cytapheresis, anti-inflammatory factors such as soluble tumor necrosis factor receptor, and interleukin-10 reduced after cytapheresis. These changes might be responsible for the efficacy of cytapheresis. In conclusion, cytapheresis is thought to be one of the effective treatments for RPGN caused by MPO-ANCA-associated vasculitis, reducing the levels of anti-inflammatory factors.",
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Hasegawa, M, Watanabe, A, Takahashi, H, Takahashi, K, Kasugai, M, Kawamura, N, Kushimoto, H, Murakami, K, Tomita, M, Nabeshima, K, Oohashi, A, Kondou, F, Ooshima, H, Hiki, Y & Sugiyama, S 2005, 'Treatment with cytapheresis for antineutrophil cytoplasmic antibody-associated renal vasculitis and its effect on anti-inflammatory factors', Therapeutic Apheresis and Dialysis, vol. 9, no. 4, pp. 297-302. https://doi.org/10.1111/j.1744-9987.2005.00285.x

Treatment with cytapheresis for antineutrophil cytoplasmic antibody-associated renal vasculitis and its effect on anti-inflammatory factors. / Hasegawa, Midori; Watanabe, Asako; Takahashi, Hiroki; Takahashi, Kazuo; Kasugai, Masami; Kawamura, Nahoko; Kushimoto, Hiroko; Murakami, Kazutaka; Tomita, Makoto; Nabeshima, Kunihiro; Oohashi, Atsushi; Kondou, Fumiko; Ooshima, Hisaji; Hiki, Yoshiyuki; Sugiyama, Satoshi.

In: Therapeutic Apheresis and Dialysis, Vol. 9, No. 4, 01.01.2005, p. 297-302.

Research output: Contribution to journalArticle

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T1 - Treatment with cytapheresis for antineutrophil cytoplasmic antibody-associated renal vasculitis and its effect on anti-inflammatory factors

AU - Hasegawa, Midori

AU - Watanabe, Asako

AU - Takahashi, Hiroki

AU - Takahashi, Kazuo

AU - Kasugai, Masami

AU - Kawamura, Nahoko

AU - Kushimoto, Hiroko

AU - Murakami, Kazutaka

AU - Tomita, Makoto

AU - Nabeshima, Kunihiro

AU - Oohashi, Atsushi

AU - Kondou, Fumiko

AU - Ooshima, Hisaji

AU - Hiki, Yoshiyuki

AU - Sugiyama, Satoshi

PY - 2005/1/1

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N2 - To evaluate the efficacy of cytapheresis for the treatment of rapidly progressive glomerulonephritis (RPGN) caused by myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis, the renal prognosis and the mortality rate at 1 year after treatment were compared between a Cytapheresis Group and a Steroid Pulse Group. The Cytapheresis Group included 10 patients who were treated with cytapheresis and oral corticosteroids. Five had granulocytapheresis with the Adacolumn (Japan Immuno Research Laboratories Co. Ltd, Takasaki, Japan) and the remaining five had leukocytapheresis with the leukocyte removal filter, Cellsorba (Asahi Medical Co. Ltd, Tokyo, Japan). The Steroid Pulse Group was comprised of 12 patients who were treated with methylprednisolone pulse therapy and oral corticosteroids. In the Cytapheresis Group, renal function recovered in 70% of the patients and the mortality rate was 10%. In the Steroid Pulse Group, renal function recovered in 66.7% and the mortality rate was 33.3%, with infection as the cause of death. Total doses of corticosteroids converted to prednisolone dose during a 1 month period, ranged from 280 mg to 1226 mg in the Cytapheresis Group. On the other hand, these dosages ranged from 2375 mg to 8380 mg in the Steroid Pulse Group. These results indicated that the mortality rate by infection could be reduced by adding cytapheresis therapy. Concerning the mechanism of cytapheresis, anti-inflammatory factors such as soluble tumor necrosis factor receptor, and interleukin-10 reduced after cytapheresis. These changes might be responsible for the efficacy of cytapheresis. In conclusion, cytapheresis is thought to be one of the effective treatments for RPGN caused by MPO-ANCA-associated vasculitis, reducing the levels of anti-inflammatory factors.

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