TY - JOUR
T1 - Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population
T2 - The Hisayama study
AU - Nagata, Masaharu
AU - Ninomiya, Toshiharu
AU - Doi, Yasufumi
AU - Yonemoto, Koji
AU - Kubo, Michiaki
AU - Hata, Jun
AU - Tsuruya, Kazuhiko
AU - Iida, Mitsuo
AU - Kiyohara, Yutaka
N1 - Funding Information:
Acknowledgements. This study was supported in part by a Grant-in-Aid for Scientific Research A (No. 18209024) from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a Health and Labour Sciences Research Grant of the Ministry of Health, Labour and Welfare (Comprehensive Research on Aging and Health: H20-Chou-ju-004). The authors thank the residents of the town of Hisayama for their participation in the survey and the staff of the Division of Health and Welfare of Hisayama for their cooperation in this study.
PY - 2010/8
Y1 - 2010/8
N2 - Background. Chronic kidney disease (CKD) is increasingly recognized as a leading public health issue. However, there are limited data assessing secular trends in the prevalence of CKD in general Asian communities.Methods. We performed three repeated cross-sectional surveys of residents aged ≥40 years in 1974 [2118 subjects (participation rate, 81.2%)], 1988 [2741 subjects (80.9%)] and 2002 [3297 subjects (77.6%)] in a Japanese community. We compared the prevalence of CKD [one or both of proteinuria and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2] and potential risk factors among the three surveys.Results. The prevalence of CKD increased significantly with time in men (13.8% [95% confidence interval (95% CI), 11.4-16.2%] in 1974, 15.9% [95% CI, 13.6-18.2%] in 1988 and 22.1% [95% CI, 19.6-24.6%] in 2002; P for trend < 0.001), but not in women (14.3% [95% CI, 12.2-16.4%], 12.6% [95% CI, 10.9-14.3%] and 15.3% [95% CI, 13.4-17.2%]; P for trend = 0.97). The frequencies of individuals with CKD Stages 3-5 (eGFR < 60 mL/min/1.73 m2) increased over the three decades in both sexes. Despite the widespread use of antihypertensive agents, the proportions of individuals with CKD who reached blood pressure of <130/80 mmHg were only 27.0% in men and 47.5% in women. The frequency of metabolic disorders including diabetes, hypercholesterolaemia and obesity increased over the three decades in both sexes.Conclusions. The prevalence of CKD increased significantly in men, but not in women over the last three decades in a general Japanese population. Our findings support the requirement for a comprehensive treatment for hypertension and metabolic disorders to reduce the burden of CKD.
AB - Background. Chronic kidney disease (CKD) is increasingly recognized as a leading public health issue. However, there are limited data assessing secular trends in the prevalence of CKD in general Asian communities.Methods. We performed three repeated cross-sectional surveys of residents aged ≥40 years in 1974 [2118 subjects (participation rate, 81.2%)], 1988 [2741 subjects (80.9%)] and 2002 [3297 subjects (77.6%)] in a Japanese community. We compared the prevalence of CKD [one or both of proteinuria and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2] and potential risk factors among the three surveys.Results. The prevalence of CKD increased significantly with time in men (13.8% [95% confidence interval (95% CI), 11.4-16.2%] in 1974, 15.9% [95% CI, 13.6-18.2%] in 1988 and 22.1% [95% CI, 19.6-24.6%] in 2002; P for trend < 0.001), but not in women (14.3% [95% CI, 12.2-16.4%], 12.6% [95% CI, 10.9-14.3%] and 15.3% [95% CI, 13.4-17.2%]; P for trend = 0.97). The frequencies of individuals with CKD Stages 3-5 (eGFR < 60 mL/min/1.73 m2) increased over the three decades in both sexes. Despite the widespread use of antihypertensive agents, the proportions of individuals with CKD who reached blood pressure of <130/80 mmHg were only 27.0% in men and 47.5% in women. The frequency of metabolic disorders including diabetes, hypercholesterolaemia and obesity increased over the three decades in both sexes.Conclusions. The prevalence of CKD increased significantly in men, but not in women over the last three decades in a general Japanese population. Our findings support the requirement for a comprehensive treatment for hypertension and metabolic disorders to reduce the burden of CKD.
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U2 - 10.1093/ndt/gfq062
DO - 10.1093/ndt/gfq062
M3 - Article
C2 - 20176610
AN - SCOPUS:77954768806
SN - 0931-0509
VL - 25
SP - 2557
EP - 2564
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
IS - 8
ER -
