Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: The Hisayama study

Masaharu Nagata, Toshiharu Ninomiya, Yasufumi Doi, Koji Yonemoto, Michiaki Kubo, Jun Hata, Kazuhiko Tsuruya, Mitsuo Iida, Yutaka Kiyohara

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Abstract

Background. Chronic kidney disease (CKD) is increasingly recognized as a leading public health issue. However, there are limited data assessing secular trends in the prevalence of CKD in general Asian communities.Methods. We performed three repeated cross-sectional surveys of residents aged ≥40 years in 1974 [2118 subjects (participation rate, 81.2%)], 1988 [2741 subjects (80.9%)] and 2002 [3297 subjects (77.6%)] in a Japanese community. We compared the prevalence of CKD [one or both of proteinuria and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2] and potential risk factors among the three surveys.Results. The prevalence of CKD increased significantly with time in men (13.8% [95% confidence interval (95% CI), 11.4-16.2%] in 1974, 15.9% [95% CI, 13.6-18.2%] in 1988 and 22.1% [95% CI, 19.6-24.6%] in 2002; P for trend < 0.001), but not in women (14.3% [95% CI, 12.2-16.4%], 12.6% [95% CI, 10.9-14.3%] and 15.3% [95% CI, 13.4-17.2%]; P for trend = 0.97). The frequencies of individuals with CKD Stages 3-5 (eGFR < 60 mL/min/1.73 m2) increased over the three decades in both sexes. Despite the widespread use of antihypertensive agents, the proportions of individuals with CKD who reached blood pressure of <130/80 mmHg were only 27.0% in men and 47.5% in women. The frequency of metabolic disorders including diabetes, hypercholesterolaemia and obesity increased over the three decades in both sexes.Conclusions. The prevalence of CKD increased significantly in men, but not in women over the last three decades in a general Japanese population. Our findings support the requirement for a comprehensive treatment for hypertension and metabolic disorders to reduce the burden of CKD.

Original languageEnglish
Pages (from-to)2557-2564
Number of pages8
JournalNephrology Dialysis Transplantation
Volume25
Issue number8
DOIs
Publication statusPublished - 01-01-2010

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Chronic Renal Insufficiency
Confidence Intervals
Population
Glomerular Filtration Rate
Hypercholesterolemia
Proteinuria
Antihypertensive Agents
Public Health
Obesity
Cross-Sectional Studies
Blood Pressure
Hypertension

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Nagata, Masaharu ; Ninomiya, Toshiharu ; Doi, Yasufumi ; Yonemoto, Koji ; Kubo, Michiaki ; Hata, Jun ; Tsuruya, Kazuhiko ; Iida, Mitsuo ; Kiyohara, Yutaka. / Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population : The Hisayama study. In: Nephrology Dialysis Transplantation. 2010 ; Vol. 25, No. 8. pp. 2557-2564.
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title = "Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: The Hisayama study",
abstract = "Background. Chronic kidney disease (CKD) is increasingly recognized as a leading public health issue. However, there are limited data assessing secular trends in the prevalence of CKD in general Asian communities.Methods. We performed three repeated cross-sectional surveys of residents aged ≥40 years in 1974 [2118 subjects (participation rate, 81.2{\%})], 1988 [2741 subjects (80.9{\%})] and 2002 [3297 subjects (77.6{\%})] in a Japanese community. We compared the prevalence of CKD [one or both of proteinuria and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2] and potential risk factors among the three surveys.Results. The prevalence of CKD increased significantly with time in men (13.8{\%} [95{\%} confidence interval (95{\%} CI), 11.4-16.2{\%}] in 1974, 15.9{\%} [95{\%} CI, 13.6-18.2{\%}] in 1988 and 22.1{\%} [95{\%} CI, 19.6-24.6{\%}] in 2002; P for trend < 0.001), but not in women (14.3{\%} [95{\%} CI, 12.2-16.4{\%}], 12.6{\%} [95{\%} CI, 10.9-14.3{\%}] and 15.3{\%} [95{\%} CI, 13.4-17.2{\%}]; P for trend = 0.97). The frequencies of individuals with CKD Stages 3-5 (eGFR < 60 mL/min/1.73 m2) increased over the three decades in both sexes. Despite the widespread use of antihypertensive agents, the proportions of individuals with CKD who reached blood pressure of <130/80 mmHg were only 27.0{\%} in men and 47.5{\%} in women. The frequency of metabolic disorders including diabetes, hypercholesterolaemia and obesity increased over the three decades in both sexes.Conclusions. The prevalence of CKD increased significantly in men, but not in women over the last three decades in a general Japanese population. Our findings support the requirement for a comprehensive treatment for hypertension and metabolic disorders to reduce the burden of CKD.",
author = "Masaharu Nagata and Toshiharu Ninomiya and Yasufumi Doi and Koji Yonemoto and Michiaki Kubo and Jun Hata and Kazuhiko Tsuruya and Mitsuo Iida and Yutaka Kiyohara",
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Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population : The Hisayama study. / Nagata, Masaharu; Ninomiya, Toshiharu; Doi, Yasufumi; Yonemoto, Koji; Kubo, Michiaki; Hata, Jun; Tsuruya, Kazuhiko; Iida, Mitsuo; Kiyohara, Yutaka.

In: Nephrology Dialysis Transplantation, Vol. 25, No. 8, 01.01.2010, p. 2557-2564.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population

T2 - The Hisayama study

AU - Nagata, Masaharu

AU - Ninomiya, Toshiharu

AU - Doi, Yasufumi

AU - Yonemoto, Koji

AU - Kubo, Michiaki

AU - Hata, Jun

AU - Tsuruya, Kazuhiko

AU - Iida, Mitsuo

AU - Kiyohara, Yutaka

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Background. Chronic kidney disease (CKD) is increasingly recognized as a leading public health issue. However, there are limited data assessing secular trends in the prevalence of CKD in general Asian communities.Methods. We performed three repeated cross-sectional surveys of residents aged ≥40 years in 1974 [2118 subjects (participation rate, 81.2%)], 1988 [2741 subjects (80.9%)] and 2002 [3297 subjects (77.6%)] in a Japanese community. We compared the prevalence of CKD [one or both of proteinuria and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2] and potential risk factors among the three surveys.Results. The prevalence of CKD increased significantly with time in men (13.8% [95% confidence interval (95% CI), 11.4-16.2%] in 1974, 15.9% [95% CI, 13.6-18.2%] in 1988 and 22.1% [95% CI, 19.6-24.6%] in 2002; P for trend < 0.001), but not in women (14.3% [95% CI, 12.2-16.4%], 12.6% [95% CI, 10.9-14.3%] and 15.3% [95% CI, 13.4-17.2%]; P for trend = 0.97). The frequencies of individuals with CKD Stages 3-5 (eGFR < 60 mL/min/1.73 m2) increased over the three decades in both sexes. Despite the widespread use of antihypertensive agents, the proportions of individuals with CKD who reached blood pressure of <130/80 mmHg were only 27.0% in men and 47.5% in women. The frequency of metabolic disorders including diabetes, hypercholesterolaemia and obesity increased over the three decades in both sexes.Conclusions. The prevalence of CKD increased significantly in men, but not in women over the last three decades in a general Japanese population. Our findings support the requirement for a comprehensive treatment for hypertension and metabolic disorders to reduce the burden of CKD.

AB - Background. Chronic kidney disease (CKD) is increasingly recognized as a leading public health issue. However, there are limited data assessing secular trends in the prevalence of CKD in general Asian communities.Methods. We performed three repeated cross-sectional surveys of residents aged ≥40 years in 1974 [2118 subjects (participation rate, 81.2%)], 1988 [2741 subjects (80.9%)] and 2002 [3297 subjects (77.6%)] in a Japanese community. We compared the prevalence of CKD [one or both of proteinuria and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2] and potential risk factors among the three surveys.Results. The prevalence of CKD increased significantly with time in men (13.8% [95% confidence interval (95% CI), 11.4-16.2%] in 1974, 15.9% [95% CI, 13.6-18.2%] in 1988 and 22.1% [95% CI, 19.6-24.6%] in 2002; P for trend < 0.001), but not in women (14.3% [95% CI, 12.2-16.4%], 12.6% [95% CI, 10.9-14.3%] and 15.3% [95% CI, 13.4-17.2%]; P for trend = 0.97). The frequencies of individuals with CKD Stages 3-5 (eGFR < 60 mL/min/1.73 m2) increased over the three decades in both sexes. Despite the widespread use of antihypertensive agents, the proportions of individuals with CKD who reached blood pressure of <130/80 mmHg were only 27.0% in men and 47.5% in women. The frequency of metabolic disorders including diabetes, hypercholesterolaemia and obesity increased over the three decades in both sexes.Conclusions. The prevalence of CKD increased significantly in men, but not in women over the last three decades in a general Japanese population. Our findings support the requirement for a comprehensive treatment for hypertension and metabolic disorders to reduce the burden of CKD.

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U2 - 10.1093/ndt/gfq062

DO - 10.1093/ndt/gfq062

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SN - 0931-0509

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