Trophinin in cell adhesion and signal transduction

Michiko N. Fukuda, Kazuhiro Sugihara

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms but by activities unique to humans. Among the latter, evidence suggests that the cell adhesion molecule trophinin plays a unique role in human embryo implantation. Here, we describe characteristics of trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells during human embryo implantation and events related to human sperm tail motility. We also report dual roles for trophinin in human cancers in terms of promoting malignancy in some tumor types and suppressing it in others.

Original languageEnglish
Pages (from-to)342-350
Number of pages9
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number1
DOIs
Publication statusPublished - 01-01-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Fingerprint

Dive into the research topics of 'Trophinin in cell adhesion and signal transduction'. Together they form a unique fingerprint.

Cite this