Trophinin: What embryo implantation teaches us about human cancer

Michiko N. Fukuda, Kazuhiro Sugihara, Jun Nakayama

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Aggressive behaviors of trophoblasts during embryo implantation resemble to those of malignant tumor cells. As much as 20-40% of all epithelial cancers in humans express human chorionic gonadotrophin (hCG), a marker for trophoblast. Therefore it is not surprising if some mechanisms are shared by cancer and trophoblast. However, the molecular basis of human embryo implantation is not well understood due to difficulties in studying the process in humans. Mechanisms of human embryo implantation are unique, as are features of trophoblastic cancer. This review describes trophinin, a cell adhesion/signaling protein, and its associated proteins, bystin and tastin, the proteins potentially involved in human embryo implantation, and presents examples of trophinin-expressing cancers.

Original languageEnglish
Pages (from-to)1165-1170
Number of pages6
JournalCancer Biology and Therapy
Issue number8
Publication statusPublished - 08-2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research


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