TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility

Chihiro Andoh, Naoya Nishitani, Emina Hashimoto, Yuma Nagai, Keizo Takao, Tsuyoshi Miyakawa, Takayuki Nakagawa, Yasuo Mori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable, nonselective cation channel and a member of the TRP channel superfamily that acts as a sensor of intracellular redox states. TRPM2 is widely distributed in many tissues and highly expressed in the brain, but the physiological roles of TRPM2 in the central nervous system remain unclear. In this study, TRPM2-deficient mice were examined in a series of behavioral tests. TRPM2-deficient mice did not significantly differ from wild-type littermates in muscle strength, light/dark transition test, rotarod, elevated plus maze, social interaction, prepulse inhibition, Y-maze, forced swim test, cued and contextual fear conditioning, and tail suspension test. In the Barnes circular maze, TRPM2-deficient mice learned the fixed escape box position at similar extent to wild-type littermates, suggesting normal reference memory. However, performance of the first reversal trial and probe test were significantly impaired in TRPM2-deficient mice. In the T-maze delayed alternation task, TRPM2 deficiency significantly reduced choice accuracy. These results indicate that TRPM2-deficient mice shows behavioral inflexibility. Meanwhile, social avoidance induced by repeated social defeat stress was significantly attenuated in TRPM2-deficient mice, suggesting that TRPM2 deficiency confers stress resiliency. Our findings indicate that TRPM2 plays an essential role in maintaining behavioral flexibility but it increases susceptibility to stress.

Original languageEnglish
Pages (from-to)68-77
Number of pages10
JournalBrain Research
Volume1704
DOIs
Publication statusPublished - 01-02-2019

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Rotarod Performance Test
Hindlimb Suspension
Muscle Strength
Interpersonal Relations
Oxidation-Reduction
Fear
Cations
Central Nervous System
Light
Brain
Prepulse Inhibition
Behavior Rating Scale
Conditioning (Psychology)

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Andoh, Chihiro ; Nishitani, Naoya ; Hashimoto, Emina ; Nagai, Yuma ; Takao, Keizo ; Miyakawa, Tsuyoshi ; Nakagawa, Takayuki ; Mori, Yasuo ; Nagayasu, Kazuki ; Shirakawa, Hisashi ; Kaneko, Shuji. / TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. In: Brain Research. 2019 ; Vol. 1704. pp. 68-77.
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Andoh, C, Nishitani, N, Hashimoto, E, Nagai, Y, Takao, K, Miyakawa, T, Nakagawa, T, Mori, Y, Nagayasu, K, Shirakawa, H & Kaneko, S 2019, 'TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility', Brain Research, vol. 1704, pp. 68-77. https://doi.org/10.1016/j.brainres.2018.09.031

TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. / Andoh, Chihiro; Nishitani, Naoya; Hashimoto, Emina; Nagai, Yuma; Takao, Keizo; Miyakawa, Tsuyoshi; Nakagawa, Takayuki; Mori, Yasuo; Nagayasu, Kazuki; Shirakawa, Hisashi; Kaneko, Shuji.

In: Brain Research, Vol. 1704, 01.02.2019, p. 68-77.

Research output: Contribution to journalArticle

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AU - Andoh, Chihiro

AU - Nishitani, Naoya

AU - Hashimoto, Emina

AU - Nagai, Yuma

AU - Takao, Keizo

AU - Miyakawa, Tsuyoshi

AU - Nakagawa, Takayuki

AU - Mori, Yasuo

AU - Nagayasu, Kazuki

AU - Shirakawa, Hisashi

AU - Kaneko, Shuji

PY - 2019/2/1

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