Tryptophan metabolism was accelerated by exercise in rat

Yasuhiro Ito, Reiko Yonekura, Kazuhiro Maruta, Takaaki Koike, Yasushi Nakagami, Katsumi Shibata, Kuniaki Saito, Yoichi Nagamura

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have already reported that exercise activates kynurenine pathway. But, the mechanism for this activation by exercise is still unclear. Kynurenine is metabolized to NAD, which is an essential factor for energy metabolism. In this study, exercise on treadmill was loaded to rats until all-out and tryptophan metabolites and tryptophan 2,3-dioxygenase (TDO) and indoleamine 2, 3-dioxygenase (IDO) activities were determined in the blood, livers, and macrophages, respectively, in the exercise-loaded rats. The mean values of serum tryptophan concentration decreased from 92.6±6.0 nmol/ml to 52.4±10.2 nmol/ml (p<0.05) just after treadmill load. The serum kynurenine concentration had increased from 2.06±0.25 nmol/ml to 3.08±0.62 nmol/ml (p<0.005). And whole blood NAD concentration increased from 68.8±14.6 nmol/ml to 77.9±19.1 nmol/ml (p<0.005). These results showed that exercise activated the kynurenine pathway of tryptophan metabolism and made NAD which will be concerned with energy metabolism in mitochondria. Tryptophan-NAD pathway was initiated by cleavage of indole ring of tryptophan by TDO in the liver and IDO in many organs. We had also found that the exercise increase IDO activity of macrophages, but not TDO activity.

Original languageEnglish
Pages (from-to)531-535
Number of pages5
JournalAdvances in Experimental Medicine and Biology
Volume527
Publication statusPublished - 01-12-2003
Externally publishedYes

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Kynurenine
Indoleamine-Pyrrole 2,3,-Dioxygenase
Metabolism
Tryptophan
NAD
Tryptophan Oxygenase
Rats
Dioxygenases
Exercise equipment
Energy Metabolism
Macrophages
Liver
Blood
Serum
Mitochondria
Metabolites
Chemical activation
tryptophyltryptophan

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ito, Y., Yonekura, R., Maruta, K., Koike, T., Nakagami, Y., Shibata, K., ... Nagamura, Y. (2003). Tryptophan metabolism was accelerated by exercise in rat. Advances in Experimental Medicine and Biology, 527, 531-535.
Ito, Yasuhiro ; Yonekura, Reiko ; Maruta, Kazuhiro ; Koike, Takaaki ; Nakagami, Yasushi ; Shibata, Katsumi ; Saito, Kuniaki ; Nagamura, Yoichi. / Tryptophan metabolism was accelerated by exercise in rat. In: Advances in Experimental Medicine and Biology. 2003 ; Vol. 527. pp. 531-535.
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Ito, Y, Yonekura, R, Maruta, K, Koike, T, Nakagami, Y, Shibata, K, Saito, K & Nagamura, Y 2003, 'Tryptophan metabolism was accelerated by exercise in rat', Advances in Experimental Medicine and Biology, vol. 527, pp. 531-535.

Tryptophan metabolism was accelerated by exercise in rat. / Ito, Yasuhiro; Yonekura, Reiko; Maruta, Kazuhiro; Koike, Takaaki; Nakagami, Yasushi; Shibata, Katsumi; Saito, Kuniaki; Nagamura, Yoichi.

In: Advances in Experimental Medicine and Biology, Vol. 527, 01.12.2003, p. 531-535.

Research output: Contribution to journalArticle

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AU - Ito, Yasuhiro

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AU - Maruta, Kazuhiro

AU - Koike, Takaaki

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AU - Shibata, Katsumi

AU - Saito, Kuniaki

AU - Nagamura, Yoichi

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Ito Y, Yonekura R, Maruta K, Koike T, Nakagami Y, Shibata K et al. Tryptophan metabolism was accelerated by exercise in rat. Advances in Experimental Medicine and Biology. 2003 Dec 1;527:531-535.