TY - JOUR
T1 - Tumor-associated fibrosis
T2 - a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
AU - Fujimoto, Hiroki
AU - Yoshihara, Masato
AU - Rodgers, Raymond
AU - Iyoshi, Shohei
AU - Mogi, Kazumasa
AU - Miyamoto, Emiri
AU - Hayakawa, Sae
AU - Hayashi, Maia
AU - Nomura, Satoshi
AU - Kitami, Kazuhisa
AU - Uno, Kaname
AU - Sugiyama, Mai
AU - Koya, Yoshihiro
AU - Yamakita, Yoshihiko
AU - Nawa, Akihiro
AU - Enomoto, Atsushi
AU - Ricciardelli, Carmela
AU - Kajiyama, Hiroaki
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/9
Y1 - 2024/9
N2 - Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.
AB - Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.
KW - Extracellular matrix
KW - Fibrosis
KW - Mesothelial
KW - Metastasis
KW - Ovarian cancer
UR - https://www.scopus.com/pages/publications/85188902858
UR - https://www.scopus.com/pages/publications/85188902858#tab=citedBy
U2 - 10.1007/s10555-024-10169-8
DO - 10.1007/s10555-024-10169-8
M3 - Review article
C2 - 38546906
AN - SCOPUS:85188902858
SN - 0167-7659
VL - 43
SP - 1037
EP - 1053
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
IS - 3
ER -
