Tumor targeting by a carbohydrate ligand-mimicking peptide

Shingo Hatakeyama, Toshiaki K. Shibata, Yuki Tobisawa, Chikara Ohyama, Kazuhiro Sugihara, Michiko N. Fukuda

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Annexin A1 (Anxa1) is a highly specific surface marker of tumor vasculature. We used peptide-displaying phage technology to identify a carbohydrate ligand-mimicking 7-mer peptide, IFLLWQR (IF7), which can target Anxa1 in tumor vasculature. Here, we describe the binding activity of carbohydrate to Anxa1, Anxa1 to heparan sulfates, and the therapeutic potential of IF7 conjugated with anticancer drugs in tumor targeting.

Original languageEnglish
Title of host publicationGlycosyltransferases
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages369-386
Number of pages18
ISBN (Print)9781627034647
DOIs
Publication statusPublished - 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1022
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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