Twenty-three patients with laryngeal papillomas and papillomatosis were examined and the clinical and pathological findings in the last nine years at our clinic are presented. There were 18 males and 5 females; 5 were juvenile and the others were adults. The multiple type of laryngeal papillomas was found in four young and one adult patients. Pathologically, the epithelia in six cases showed remarkable hyperkeratosis with papillomatous invasion into the basal membrane, suggestive of malignancy. Two of them were harboring occult cancer according to detailed re-examination. After several years, papillomas in the larynx were altered to cancer in the other patients. Electron microscopy performed in some patients did not reveal virus particles in the nucleus of epithelial cells in this disease.
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