Two cases of occupational contact urticaria caused by percutaneous sensitization to parvalbumin

Akiyo Sano, Akiko Yagami, Kayoko Suzuki, Yohei Iwata, Tsukane Kobayashi, Masaru Arima, Yasuto Kondo, Tetsushi Yoshikawa, Kayoko Matsunaga

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: In recent years, it has been proposed that the primary mechanism for the development of food allergies is percutaneous sensitization. Since 2010, in Japan, the number of immediate-type wheat allergy due to hydrolyzed wheat protein has dramatically increased among those who have been using soap containing hydrolyzed wheat. This incidence supports the hypothesis that food allergens arise through percutaneous sensitization. Clinical Summary: A 25-year-old man (case 1) and an 18-year-old girl (case 2) with atopic dermatitis visited our Department because of food allergy and hand eczema. After starting their work with fish, severe itchy eczema appeared on their hands. They subsequently started to experience oral allergic symptoms, intraoral itchiness and dyspnea after eating fish. Specific IgE antibodies were detected for many fishes, and skin prick tests showed positive reactions for a variety of fishes in both cases. Furthermore, the fluorescence intensities of specific IgE antibodies against parvalbumin from various types of fish in microarray immunoassay analysis showed positive reactions. We diagnosed them as contact urticaria caused by percutaneous sensitization to parvalbumin through job-related physical contact with fish. Conclusion: The patients' histories and findings indicate the possibility of percutaneous sensitization through occupational exposure to parvalbumin, leading to food allergy.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalCase Reports in Dermatology
Volume7
DOIs
Publication statusPublished - 07-05-2015

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Parvalbumins
Urticaria
Fishes
Food Hypersensitivity
Eczema
Immunoglobulin E
Triticum
Wheat Hypersensitivity
Hand
Soaps
Antibodies
Occupational Exposure
Microarray Analysis
Skin Tests
Immunoassay
Dyspnea
Allergens
Japan
Eating
Fluorescence

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Sano, Akiyo ; Yagami, Akiko ; Suzuki, Kayoko ; Iwata, Yohei ; Kobayashi, Tsukane ; Arima, Masaru ; Kondo, Yasuto ; Yoshikawa, Tetsushi ; Matsunaga, Kayoko. / Two cases of occupational contact urticaria caused by percutaneous sensitization to parvalbumin. In: Case Reports in Dermatology. 2015 ; Vol. 7. pp. 227-232.
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Two cases of occupational contact urticaria caused by percutaneous sensitization to parvalbumin. / Sano, Akiyo; Yagami, Akiko; Suzuki, Kayoko; Iwata, Yohei; Kobayashi, Tsukane; Arima, Masaru; Kondo, Yasuto; Yoshikawa, Tetsushi; Matsunaga, Kayoko.

In: Case Reports in Dermatology, Vol. 7, 07.05.2015, p. 227-232.

Research output: Contribution to journalArticle

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