TY - JOUR
T1 - Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases
AU - Kobayashi, Motohiro
AU - Hoshino, Hitomi
AU - Suzawa, Kenichi
AU - Sakai, Yasuhiro
AU - Nakayama, Jun
AU - Fukuda, Minoru
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/5
Y1 - 2012/5
N2 - Abstract Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin a4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin a4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.
AB - Abstract Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin a4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin a4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.
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U2 - 10.1007/s00281-012-0302-3
DO - 10.1007/s00281-012-0302-3
M3 - Article
C2 - 22572886
AN - SCOPUS:84866118543
VL - 34
SP - 401
EP - 413
JO - Seminars in Immunopathology
JF - Seminars in Immunopathology
SN - 1863-2297
IS - 3
ER -