Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases

Motohiro Kobayashi; Hitomi Hoshino; Kenichi Suzawa; Yasuhiro Sakai; Jun Nakayama; Minoru Fukuda

doi:10.1007/s00281-012-0302-3

Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases

Motohiro Kobayashi, Hitomi Hoshino, Kenichi Suzawa, Yasuhiro Sakai, Jun Nakayama, Minoru Fukuda

Diagnostic pathology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Abstract Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin a4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin a4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.

Original language	English
Pages (from-to)	401-413
Number of pages	13
Journal	Seminars in Immunopathology
Volume	34
Issue number	3
DOIs	https://doi.org/10.1007/s00281-012-0302-3
Publication status	Published - 05-2012

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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Cite this

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title = "Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases",

abstract = "Abstract Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin a4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin a4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.",

author = "Motohiro Kobayashi and Hitomi Hoshino and Kenichi Suzawa and Yasuhiro Sakai and Jun Nakayama and Minoru Fukuda",

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T1 - Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases

AU - Kobayashi, Motohiro

AU - Hoshino, Hitomi

AU - Suzawa, Kenichi

AU - Sakai, Yasuhiro

AU - Nakayama, Jun

AU - Fukuda, Minoru

PY - 2012/5

Y1 - 2012/5

N2 - Abstract Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin a4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin a4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.

AB - Abstract Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin a4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin a4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.

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