Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases

Motohiro Kobayashi, Hitomi Hoshino, Kenichi Suzawa, Yasuhiro Sakai, Jun Nakayama, Minoru Fukuda

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Abstract Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin a4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin a4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.

Original languageEnglish
Pages (from-to)401-413
Number of pages13
JournalSeminars in Immunopathology
Volume34
Issue number3
DOIs
Publication statusPublished - 05-2012

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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