TY - JOUR
T1 - Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases
AU - Kobayashi, Motohiro
AU - Hoshino, Hitomi
AU - Suzawa, Kenichi
AU - Sakai, Yasuhiro
AU - Nakayama, Jun
AU - Fukuda, Minoru
N1 - Funding Information:
We thank the members of the Fukudas’ and Nakayama’s laboratories for their critical contribution to the studies and useful discussion. We also thank Dr. Elise Lamar for critical reading of the manuscript. The work reviewed from our laboratories has been supported by Grants-in-Aid for Young Scientist B-18790240, B-20790278, and B-22790343 (to M.K.), for Scientific Research on Priority Area 14082201 (to J.N) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, Grant-in-Aid for Scientific Research B-18390113 and B-21390104 from the Japan Society for the Promotion of Science (to J.N.), and Grants RO1 CA48737 and CA33000 and PO1 CA71932 from the National Institutes of Health (to M.F.).
PY - 2012/5
Y1 - 2012/5
N2 - Abstract Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin a4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin a4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.
AB - Abstract Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin a4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin a4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.
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U2 - 10.1007/s00281-012-0302-3
DO - 10.1007/s00281-012-0302-3
M3 - Article
C2 - 22572886
AN - SCOPUS:84866118543
VL - 34
SP - 401
EP - 413
JO - Seminars in Immunopathology
JF - Seminars in Immunopathology
SN - 1863-2297
IS - 3
ER -