Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms

Satoru Kobayashi, Yutaka Negishi, Naoki Ando, Tetsuya Ito, Masao Nakano, Hajime Togari, Mitsutaka Wakuda, Koki Taniguchi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Rotavirus, one of the major causes of severe gastroenteritis in children, occasionally causes central nervous system complications. Recently several patients with acute encephalitis/encephalopathy due to rotavirus associated with cerebellar signs and symptoms have been reported. The condition is characterized by disturbances of consciousness at onset and cerebellar signs and symptoms such as hypotonia, ataxia, dysmetria, and speech disorders, including mutism, slow speech, and dysarthria at convalescence. We report two patients (3-year-old girl, 2-year-old boy) who developed acute encephalitis due to rotavirus and showed cerebellar signs and symptoms. Both patients had characteristic history of consciousness disturbances subsequent to several days of diarrhea, vomiting and fever, and cerebellar symptoms such as hypotonia, ataxia, dysmetria, and speech disorders during the recovery period. Electroencephalography showed diffuse high-voltage delta wave activity in each patient. Brain magnetic resonance imaging showed cerebellar edema in the acute phase followed by cerebellar atrophy on follow-up images in both patients. In the first patient, diffusion-weighted images (DWI) revealed high signals at the left cerebellar peduncle region and apparent diffusion coefficient (ADC) maps showed decreased ADC values of the lesion in the acute phase. The first patient had dysmetria at 1-year follow-up. However, she had normal motor and cognitive functions and could lead her daily life without impairment. In the second patient, no further symptoms were apparent at 1-year follow-up. Acute encephalitis/encephalopathy due to rotavirus with cerebellar signs and symptoms might be diagnosed on DWI, by demonstrating decreased ADC values in acute phase.

Original languageEnglish
Pages (from-to)1287-1291
Number of pages5
JournalEuropean Journal of Pediatrics
Volume169
Issue number10
DOIs
Publication statusPublished - 01-10-2010
Externally publishedYes

Fingerprint

Rotavirus
Encephalitis
Signs and Symptoms
Cerebellar Ataxia
Speech Disorders
Muscle Hypotonia
Brain Diseases
Ataxia
Consciousness
Mutism
Dysarthria
Gastroenteritis
Cognition
Atrophy
Vomiting
Electroencephalography
Diarrhea
Edema
Fever
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Kobayashi, Satoru ; Negishi, Yutaka ; Ando, Naoki ; Ito, Tetsuya ; Nakano, Masao ; Togari, Hajime ; Wakuda, Mitsutaka ; Taniguchi, Koki. / Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms. In: European Journal of Pediatrics. 2010 ; Vol. 169, No. 10. pp. 1287-1291.
@article{f2f31554539b418081bec8c9c94acc33,
title = "Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms",
abstract = "Rotavirus, one of the major causes of severe gastroenteritis in children, occasionally causes central nervous system complications. Recently several patients with acute encephalitis/encephalopathy due to rotavirus associated with cerebellar signs and symptoms have been reported. The condition is characterized by disturbances of consciousness at onset and cerebellar signs and symptoms such as hypotonia, ataxia, dysmetria, and speech disorders, including mutism, slow speech, and dysarthria at convalescence. We report two patients (3-year-old girl, 2-year-old boy) who developed acute encephalitis due to rotavirus and showed cerebellar signs and symptoms. Both patients had characteristic history of consciousness disturbances subsequent to several days of diarrhea, vomiting and fever, and cerebellar symptoms such as hypotonia, ataxia, dysmetria, and speech disorders during the recovery period. Electroencephalography showed diffuse high-voltage delta wave activity in each patient. Brain magnetic resonance imaging showed cerebellar edema in the acute phase followed by cerebellar atrophy on follow-up images in both patients. In the first patient, diffusion-weighted images (DWI) revealed high signals at the left cerebellar peduncle region and apparent diffusion coefficient (ADC) maps showed decreased ADC values of the lesion in the acute phase. The first patient had dysmetria at 1-year follow-up. However, she had normal motor and cognitive functions and could lead her daily life without impairment. In the second patient, no further symptoms were apparent at 1-year follow-up. Acute encephalitis/encephalopathy due to rotavirus with cerebellar signs and symptoms might be diagnosed on DWI, by demonstrating decreased ADC values in acute phase.",
author = "Satoru Kobayashi and Yutaka Negishi and Naoki Ando and Tetsuya Ito and Masao Nakano and Hajime Togari and Mitsutaka Wakuda and Koki Taniguchi",
year = "2010",
month = "10",
day = "1",
doi = "10.1007/s00431-010-1202-y",
language = "English",
volume = "169",
pages = "1287--1291",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer Verlag",
number = "10",

}

Kobayashi, S, Negishi, Y, Ando, N, Ito, T, Nakano, M, Togari, H, Wakuda, M & Taniguchi, K 2010, 'Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms', European Journal of Pediatrics, vol. 169, no. 10, pp. 1287-1291. https://doi.org/10.1007/s00431-010-1202-y

Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms. / Kobayashi, Satoru; Negishi, Yutaka; Ando, Naoki; Ito, Tetsuya; Nakano, Masao; Togari, Hajime; Wakuda, Mitsutaka; Taniguchi, Koki.

In: European Journal of Pediatrics, Vol. 169, No. 10, 01.10.2010, p. 1287-1291.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms

AU - Kobayashi, Satoru

AU - Negishi, Yutaka

AU - Ando, Naoki

AU - Ito, Tetsuya

AU - Nakano, Masao

AU - Togari, Hajime

AU - Wakuda, Mitsutaka

AU - Taniguchi, Koki

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Rotavirus, one of the major causes of severe gastroenteritis in children, occasionally causes central nervous system complications. Recently several patients with acute encephalitis/encephalopathy due to rotavirus associated with cerebellar signs and symptoms have been reported. The condition is characterized by disturbances of consciousness at onset and cerebellar signs and symptoms such as hypotonia, ataxia, dysmetria, and speech disorders, including mutism, slow speech, and dysarthria at convalescence. We report two patients (3-year-old girl, 2-year-old boy) who developed acute encephalitis due to rotavirus and showed cerebellar signs and symptoms. Both patients had characteristic history of consciousness disturbances subsequent to several days of diarrhea, vomiting and fever, and cerebellar symptoms such as hypotonia, ataxia, dysmetria, and speech disorders during the recovery period. Electroencephalography showed diffuse high-voltage delta wave activity in each patient. Brain magnetic resonance imaging showed cerebellar edema in the acute phase followed by cerebellar atrophy on follow-up images in both patients. In the first patient, diffusion-weighted images (DWI) revealed high signals at the left cerebellar peduncle region and apparent diffusion coefficient (ADC) maps showed decreased ADC values of the lesion in the acute phase. The first patient had dysmetria at 1-year follow-up. However, she had normal motor and cognitive functions and could lead her daily life without impairment. In the second patient, no further symptoms were apparent at 1-year follow-up. Acute encephalitis/encephalopathy due to rotavirus with cerebellar signs and symptoms might be diagnosed on DWI, by demonstrating decreased ADC values in acute phase.

AB - Rotavirus, one of the major causes of severe gastroenteritis in children, occasionally causes central nervous system complications. Recently several patients with acute encephalitis/encephalopathy due to rotavirus associated with cerebellar signs and symptoms have been reported. The condition is characterized by disturbances of consciousness at onset and cerebellar signs and symptoms such as hypotonia, ataxia, dysmetria, and speech disorders, including mutism, slow speech, and dysarthria at convalescence. We report two patients (3-year-old girl, 2-year-old boy) who developed acute encephalitis due to rotavirus and showed cerebellar signs and symptoms. Both patients had characteristic history of consciousness disturbances subsequent to several days of diarrhea, vomiting and fever, and cerebellar symptoms such as hypotonia, ataxia, dysmetria, and speech disorders during the recovery period. Electroencephalography showed diffuse high-voltage delta wave activity in each patient. Brain magnetic resonance imaging showed cerebellar edema in the acute phase followed by cerebellar atrophy on follow-up images in both patients. In the first patient, diffusion-weighted images (DWI) revealed high signals at the left cerebellar peduncle region and apparent diffusion coefficient (ADC) maps showed decreased ADC values of the lesion in the acute phase. The first patient had dysmetria at 1-year follow-up. However, she had normal motor and cognitive functions and could lead her daily life without impairment. In the second patient, no further symptoms were apparent at 1-year follow-up. Acute encephalitis/encephalopathy due to rotavirus with cerebellar signs and symptoms might be diagnosed on DWI, by demonstrating decreased ADC values in acute phase.

UR - http://www.scopus.com/inward/record.url?scp=77956181529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956181529&partnerID=8YFLogxK

U2 - 10.1007/s00431-010-1202-y

DO - 10.1007/s00431-010-1202-y

M3 - Article

VL - 169

SP - 1287

EP - 1291

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

IS - 10

ER -