We investigated two patients with eosinophilic granuloma of the soft tissue clinically and pathologically. Case No. 1, an 11-year-old boy, visited us in 1981 with a subcutaneous nodule on the right lower jaw. An egg-sized and elastic hard nodule was palpable on the right angle of his lower jaw. X-ray of the jaw and sialography for the right submandibular gland were normal. Serum IgE was elevated (7200 IU/ml) and there was 39% eosinophilia while WBC was 6900 per cu.mm. He was diagnosed pathologically to have eosinophilic granuloma of the soft tissue. The nodule at the right lower jaw was resolved and disappeared after he received steroid hormone and specific hyposensitization with house dust. Case No. 2. a 46-year-old man, had a nodule in his right cheek region since 1978. He had been treated with X-ray and steroid hormone at another infirmary for eosinophilic granuloma of the soft tissue but the lesion had not disappeared completely. When he was given DSCG nasal spray for his nasal allergy at our infirmary, the nodule on his right cheek region gradually decreased and tended to become soft. Atopic allergy seems to be related with the disease in our series, although further substantiation is required.
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