Two phenotypically distinct B lymphocytes (IgM(high)IgD(low) and IgM(low)IgD(high)) in chronic gastric ulcer in the rat

N. Ohmiya, M. Ito, M. Ohbayashi, T. Arisawa, H. Goto, Y. Tsukamoto, T. Hayakawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We determined the kinetics and phenotypes of infiltrating B cells in gastric ulcer in the rat induced by gastric injection of acetic acid (day 0). Few B cells were found in the lesion in the early stages of ulceration. On day 40, two kinds of B cells with phenotypes of IgM(high)IgD(low)OX33 (CD45)+OX19 (CD5)- and IgM(low)IgD(high)OX33 (CD45)+OX19 (CD5)- were scattered in the granulation tissue of open ulcers, but not in the healed scar tissue. On day 180, those two kinds of B cells formed primary follicles in the granulation tissue of open ulcers, but were absent from the healed scar tissue. The IgM(high)IgD(low)OX33 (CD45)+OX19 (CD5)- B cell was considered to be identical to the marginal zone B cell of rat spleen. This phenotype of B cell might be associated with inflammatory process in chronic gastric ulcer.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalClinical and Experimental Immunology
Volume100
Issue number1
Publication statusPublished - 01-01-1995

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Immunoglobulin D
Stomach Ulcer
Immunoglobulin M
B-Lymphocytes
Granulation Tissue
Phenotype
Ulcer
Cicatrix
Acetic Acid
Stomach
Spleen
Injections

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Ohmiya, N. ; Ito, M. ; Ohbayashi, M. ; Arisawa, T. ; Goto, H. ; Tsukamoto, Y. ; Hayakawa, T. / Two phenotypically distinct B lymphocytes (IgM(high)IgD(low) and IgM(low)IgD(high)) in chronic gastric ulcer in the rat. In: Clinical and Experimental Immunology. 1995 ; Vol. 100, No. 1. pp. 151-156.
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Ohmiya, N, Ito, M, Ohbayashi, M, Arisawa, T, Goto, H, Tsukamoto, Y & Hayakawa, T 1995, 'Two phenotypically distinct B lymphocytes (IgM(high)IgD(low) and IgM(low)IgD(high)) in chronic gastric ulcer in the rat', Clinical and Experimental Immunology, vol. 100, no. 1, pp. 151-156.

Two phenotypically distinct B lymphocytes (IgM(high)IgD(low) and IgM(low)IgD(high)) in chronic gastric ulcer in the rat. / Ohmiya, N.; Ito, M.; Ohbayashi, M.; Arisawa, T.; Goto, H.; Tsukamoto, Y.; Hayakawa, T.

In: Clinical and Experimental Immunology, Vol. 100, No. 1, 01.01.1995, p. 151-156.

Research output: Contribution to journalArticle

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AU - Goto, H.

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AU - Hayakawa, T.

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