Ultra high resolution pinhole SPECT for small animal study

K. Ogawa, T. Kawade, K. Nakamura, A. Kubo, Takashi Ichihara

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62 Citations (Scopus)


The aim of the study is to develop an ultra high-resolution pinhole SPECT system and analyze the performance by simulations. The pinhole SPECT was conducted with a Toshiba GCA-7200A gamma camera. The diameter of the pinhole was 1 mm. Data were acquired with a 128×128 matrix, and the distance from the center of rotation (COR) to the pinhole was 20 mm [case 1] or 28 mm [case 2J. The data were collected at 4 degree increments over 360 degrees. The Feldkamp method was used for image reconstruction. Before the image reconstruction, we corrected the COR of the pinhole collimator. The imaging voxel was 0.27×0.27×0.27 mm3 [case 1] or 0.4×0.4×.4 mm3 [case 2J. From the experiments with a resolution phantom the spatial resolution (FWHM) was 1.1 mm [case 1] or 1.3 mm [case 2J. The pinhole SPECT was also examined for in vivo imaging for studies of the heart in mice which were injected with Tc-99m-Tetrofosmin intravenously. In the reconstructed image the heart muscle of the mouse was clearly visualized. We also investigated the spatial resolution of the reconstructed image by means of simulations.

Original languageEnglish
Pages (from-to)3122-3126
Number of pages5
JournalIEEE Transactions on Nuclear Science
Issue number6
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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