Ultraviolet irradiation-mediated malignant melanoma induction with RET tyrosine kinase activation

Masashi Kato, Kozue Takeda, Yoshiyuki Kawamoto, Khaled Hossain, Nobutaka Ohgami, Takeshi Yanagishita, Yuichiro Ohshima, Yoko Kato, Kyoko Ohgami, Tatsuya Yamamori, Keisuke Tateyama, Osamu Yamanoshita

Research output: Contribution to journalReview articlepeer-review

Abstract

We previously established a RET-transgenic mouse line (304/B6), in which skin melanosis, benign melanocytic tumors and malignant melanoma spontaneously develop. We found that the activities of RET tyrosine kinase, Erk and c-Jun are definitely upregulated in malignant melanoma in the RET-transgenic mice of line 304/B6. We also established another RET-transgenic mouse line (192), in which skin melanosis and benign melanocytic tumors, but not malignant melanoma, spontaneously develop. Ultraviolet irradiation induced malignant melanoma from benign tumors in the RET-transgenic mice of line 192, and promoted RET tyrosine kinase, Erk and c-Jun activities. These results suggest that the ultraviolet irradiation-mediated enhancement of RET and the activity of its downstream molecules play important roles in malignant melanoma development.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalNippon eiseigaku zasshi. Japanese journal of hygiene
Volume62
Issue number1
DOIs
Publication statusPublished - 01-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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