Unchanged cytokine production under exposure of excess manganese

Y. Okamoto, T. Nagai, T. Abe, S. Ishikawa, H. Ishizuka, M. Nishida

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Manganese (Mn) plays essential physiological roles, but the effect of excess Mn on immune system has not been reported. In the present study, we examined the frequency of cytokine-secreting cells and the production of cytokines in the excess Mn-treated mice using enzyme-linked immunospot (ELISPOT) assay and enzyme-linked Immunosorbent assay (ELISA). The results indicated that the severe exposure of hosts's immune system to excess Mn neither caused drastic changes in the frequency nor cytokine production unless the cell viability was affected by the Mn levels.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalBiomedical Research
Issue number3
Publication statusPublished - 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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