Unchanged cytokine production under exposure of excess manganese

Y. Okamoto; T. Nagai; T. Abe; S. Ishikawa; H. Ishizuka; M. Nishida

Unchanged cytokine production under exposure of excess manganese

Y. Okamoto, T. Nagai, T. Abe, S. Ishikawa, H. Ishizuka, M. Nishida

Research output: Contribution to journal › Article › peer-review

Abstract

Manganese (Mn) plays essential physiological roles, but the effect of excess Mn on immune system has not been reported. In the present study, we examined the frequency of cytokine-secreting cells and the production of cytokines in the excess Mn-treated mice using enzyme-linked immunospot (ELISPOT) assay and enzyme-linked Immunosorbent assay (ELISA). The results indicated that the severe exposure of hosts's immune system to excess Mn neither caused drastic changes in the frequency nor cytokine production unless the cell viability was affected by the Mn levels.

Original language	English
Pages (from-to)	179-185
Number of pages	7
Journal	Biomedical Research
Volume	9
Issue number	3
Publication status	Published - 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Cite this

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title = "Unchanged cytokine production under exposure of excess manganese",

abstract = "Manganese (Mn) plays essential physiological roles, but the effect of excess Mn on immune system has not been reported. In the present study, we examined the frequency of cytokine-secreting cells and the production of cytokines in the excess Mn-treated mice using enzyme-linked immunospot (ELISPOT) assay and enzyme-linked Immunosorbent assay (ELISA). The results indicated that the severe exposure of hosts's immune system to excess Mn neither caused drastic changes in the frequency nor cytokine production unless the cell viability was affected by the Mn levels.",

author = "Y. Okamoto and T. Nagai and T. Abe and S. Ishikawa and H. Ishizuka and M. Nishida",

year = "1998",

language = "English",

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journal = "Biomedical Research",

issn = "0970-938X",

publisher = "Scientific Publishers of India",

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TY - JOUR

T1 - Unchanged cytokine production under exposure of excess manganese

AU - Okamoto, Y.

AU - Nagai, T.

AU - Abe, T.

AU - Ishikawa, S.

AU - Ishizuka, H.

AU - Nishida, M.

PY - 1998

Y1 - 1998

N2 - Manganese (Mn) plays essential physiological roles, but the effect of excess Mn on immune system has not been reported. In the present study, we examined the frequency of cytokine-secreting cells and the production of cytokines in the excess Mn-treated mice using enzyme-linked immunospot (ELISPOT) assay and enzyme-linked Immunosorbent assay (ELISA). The results indicated that the severe exposure of hosts's immune system to excess Mn neither caused drastic changes in the frequency nor cytokine production unless the cell viability was affected by the Mn levels.

AB - Manganese (Mn) plays essential physiological roles, but the effect of excess Mn on immune system has not been reported. In the present study, we examined the frequency of cytokine-secreting cells and the production of cytokines in the excess Mn-treated mice using enzyme-linked immunospot (ELISPOT) assay and enzyme-linked Immunosorbent assay (ELISA). The results indicated that the severe exposure of hosts's immune system to excess Mn neither caused drastic changes in the frequency nor cytokine production unless the cell viability was affected by the Mn levels.

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M3 - Article

AN - SCOPUS:0031762608

SN - 0970-938X

VL - 9

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JO - Biomedical Research

JF - Biomedical Research

IS - 3

ER -

Unchanged cytokine production under exposure of excess manganese

Abstract

All Science Journal Classification (ASJC) codes

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