TY - JOUR
T1 - Undifferentiated sarcoma of the salivary gland in a mongolian gerbil (Meriones unguiculatus)
AU - Toyoda, Takeshi
AU - Tsukamoto, Tetsuya
AU - Cho, Young Man
AU - Onami, Saeko
AU - Takasu, Shinji
AU - Shi, Liang
AU - Saito, Ayumi
AU - Matsuo, Saori
AU - Tatematsu, Masae
AU - Nishikawa, Akiyoshi
AU - Ogawa, Kumiko
PY - 2011/10/13
Y1 - 2011/10/13
N2 - A subcutaneous mass was found in the lower ventral neck region of a 55-week-old male Mongolian gerbil (Meriones unguiculatus). Histopathologically, the mass involved salivary glands and featured diffuse proliferation of pleomorphic neoplastic cells with large necrotic foci. The lesion was well demarcated from the surrounding tissue, although invasive growth to fibrous septa was occasionally observed. The neoplastic cells were mainly arranged in irregular sheets with severe cellular atypia, round to oval nuclei and varying amounts of eosinophilic cytoplasm. Mitotic figures and multinucleated giant cells were frequent. Immunohistochemical analysis revealed that the neoplastic cells were strongly positive for vimentin and S-100 and negative for NSE, cytokeratin, α-SMA, c-kit, factor VIII, CD34, α-1-antitrypsin, lysozyme and MSR-A. Based on the results, the mass was diagnosed as an undifferentiated sarcoma of the salivary gland. To the best of our knowledge, this is the first report of such a tumor in Mongolian gerbils.
AB - A subcutaneous mass was found in the lower ventral neck region of a 55-week-old male Mongolian gerbil (Meriones unguiculatus). Histopathologically, the mass involved salivary glands and featured diffuse proliferation of pleomorphic neoplastic cells with large necrotic foci. The lesion was well demarcated from the surrounding tissue, although invasive growth to fibrous septa was occasionally observed. The neoplastic cells were mainly arranged in irregular sheets with severe cellular atypia, round to oval nuclei and varying amounts of eosinophilic cytoplasm. Mitotic figures and multinucleated giant cells were frequent. Immunohistochemical analysis revealed that the neoplastic cells were strongly positive for vimentin and S-100 and negative for NSE, cytokeratin, α-SMA, c-kit, factor VIII, CD34, α-1-antitrypsin, lysozyme and MSR-A. Based on the results, the mass was diagnosed as an undifferentiated sarcoma of the salivary gland. To the best of our knowledge, this is the first report of such a tumor in Mongolian gerbils.
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U2 - 10.1293/tox.24.173
DO - 10.1293/tox.24.173
M3 - Article
C2 - 22272058
AN - SCOPUS:83155172552
SN - 0914-9198
VL - 24
SP - 173
EP - 177
JO - Journal of Toxicologic Pathology
JF - Journal of Toxicologic Pathology
IS - 3
ER -