Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

Hiroki Kurahashi, Beverly S. Emanuel

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.

Original languageEnglish
Pages (from-to)139-140
Number of pages2
JournalNature Genetics
Volume29
Issue number2
DOIs
Publication statusPublished - 22-10-2001
Externally publishedYes

Fingerprint

Spermatozoa
Chromosome Breakage
Polymerase Chain Reaction
DNA
Meiosis
Incidence

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics

Cite this

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Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males. / Kurahashi, Hiroki; Emanuel, Beverly S.

In: Nature Genetics, Vol. 29, No. 2, 22.10.2001, p. 139-140.

Research output: Contribution to journalArticle

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