Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

Hiroki Kurahashi; Beverly S. Emanuel

doi:10.1038/ng1001-139

Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

Hiroki Kurahashi, Beverly S. Emanuel

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.

Original language	English
Pages (from-to)	139-140
Number of pages	2
Journal	Nature Genetics
Volume	29
Issue number	2
DOIs	https://doi.org/10.1038/ng1001-139
Publication status	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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10.1038/ng1001-139

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title = "Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males",

abstract = "Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.",

author = "Hiroki Kurahashi and Emanuel, {Beverly S.}",

note = "Funding Information: We would like to thank H. Kono, L. Mitchell, R. Wilson and C. Felix for helpful discussions. These studies were supported in part by CA39926 (BSE), HD26979 from the NIH, and funds from the Charles E.H. Upham chair (BSE).",

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AU - Emanuel, Beverly S.

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PY - 2001

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N2 - Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.

AB - Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.

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Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

Abstract

All Science Journal Classification (ASJC) codes

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