TY - GEN
T1 - UNIDIRECTIONAL ANALYSIS OF CARDIAC PROPAGATION VELOCITY BY HUMAN IPSC-DERIVED CARDIAC CORE-SHELL MICROFIBER
AU - Masuda, Akari
AU - Itai, Shun
AU - Kurashina, Yuta
AU - Tohyama, Shugo
AU - Onoe, Hiroaki
N1 - Publisher Copyright:
© 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2022
Y1 - 2022
N2 - We propose a simple and quantitative assessment of cardiac maturation by calcium propagation velocity. A microfiber-shaped cardiac tissue enables the uniform orientation of cardiomyocyte along the fiber direction, allowing the easy calculation of propagation velocities by one-way-transmission of signals over a long distance. We evaluated the maturation of our microfiber tissues by electrical stimulation and detected 26% increase in the propagation velocity comparing to the immature tissue. Our system of maturity assessment would contribute to the construction of matured cardiac model as a platform for elucidating the pathology of cardiac diseases and drug effects.
AB - We propose a simple and quantitative assessment of cardiac maturation by calcium propagation velocity. A microfiber-shaped cardiac tissue enables the uniform orientation of cardiomyocyte along the fiber direction, allowing the easy calculation of propagation velocities by one-way-transmission of signals over a long distance. We evaluated the maturation of our microfiber tissues by electrical stimulation and detected 26% increase in the propagation velocity comparing to the immature tissue. Our system of maturity assessment would contribute to the construction of matured cardiac model as a platform for elucidating the pathology of cardiac diseases and drug effects.
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M3 - Conference contribution
AN - SCOPUS:85175738833
T3 - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 362
EP - 363
BT - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022
Y2 - 23 October 2022 through 27 October 2022
ER -