Abstract
In the G-protein-coupled receptor superfamily, the opioid receptor subfamily is constituted of the three distinct opioid receptors (namely δ-, μ- and κ-subtypes) and the receptor for nociceptin (also designated orphaninFQ). The members of the opioid receptor subfamily were known to mediate a variety of cellular inhibitory effects. The three opioid receptors are known to play central roles in mediating analgesia and many other physiological activities; however, the nociceptin receptor was identified recently and less is known about its physiological roles. Here we report the generation and characterization of mice lacking the nociceptin receptor. The knockout mice showed no significant differences in nociceptive threshold and locomotor activity compared with control mice, but they lost nociceptin-induced behavioral responses. These results indicate that the nociceptin system is not essential for regulation of nociception or locomotor activity. On the other hand, we found insufficient recovery of hearing ability from the adaptation to sound exposure in the mutant mice. Thus, the nociceptin system appears to participate in the regulation of the auditory system.
| Original language | English |
|---|---|
| Pages (from-to) | 1858-1864 |
| Number of pages | 7 |
| Journal | EMBO Journal |
| Volume | 16 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 15-04-1997 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
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Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor. / Nishi, Miyuki; Houtani, Takeshi; Noda, Yukihiro; Mamiya, Takayoshi; Sato, Kazuo; Doi, Tadashi; Kuno, Junko; Takeshima, Hiroshi; Nukada, Toshihide; Nabeshima, Toshitaka; Yamashita, Toshio; Noda, Tetsuo; Sugimoto, Tetsuo.
In: EMBO Journal, Vol. 16, No. 8, 15.04.1997, p. 1858-1864.Research output: Contribution to journal › Article
TY - JOUR
T1 - Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor
AU - Nishi, Miyuki
AU - Houtani, Takeshi
AU - Noda, Yukihiro
AU - Mamiya, Takayoshi
AU - Sato, Kazuo
AU - Doi, Tadashi
AU - Kuno, Junko
AU - Takeshima, Hiroshi
AU - Nukada, Toshihide
AU - Nabeshima, Toshitaka
AU - Yamashita, Toshio
AU - Noda, Tetsuo
AU - Sugimoto, Tetsuo
PY - 1997/4/15
Y1 - 1997/4/15
N2 - In the G-protein-coupled receptor superfamily, the opioid receptor subfamily is constituted of the three distinct opioid receptors (namely δ-, μ- and κ-subtypes) and the receptor for nociceptin (also designated orphaninFQ). The members of the opioid receptor subfamily were known to mediate a variety of cellular inhibitory effects. The three opioid receptors are known to play central roles in mediating analgesia and many other physiological activities; however, the nociceptin receptor was identified recently and less is known about its physiological roles. Here we report the generation and characterization of mice lacking the nociceptin receptor. The knockout mice showed no significant differences in nociceptive threshold and locomotor activity compared with control mice, but they lost nociceptin-induced behavioral responses. These results indicate that the nociceptin system is not essential for regulation of nociception or locomotor activity. On the other hand, we found insufficient recovery of hearing ability from the adaptation to sound exposure in the mutant mice. Thus, the nociceptin system appears to participate in the regulation of the auditory system.
AB - In the G-protein-coupled receptor superfamily, the opioid receptor subfamily is constituted of the three distinct opioid receptors (namely δ-, μ- and κ-subtypes) and the receptor for nociceptin (also designated orphaninFQ). The members of the opioid receptor subfamily were known to mediate a variety of cellular inhibitory effects. The three opioid receptors are known to play central roles in mediating analgesia and many other physiological activities; however, the nociceptin receptor was identified recently and less is known about its physiological roles. Here we report the generation and characterization of mice lacking the nociceptin receptor. The knockout mice showed no significant differences in nociceptive threshold and locomotor activity compared with control mice, but they lost nociceptin-induced behavioral responses. These results indicate that the nociceptin system is not essential for regulation of nociception or locomotor activity. On the other hand, we found insufficient recovery of hearing ability from the adaptation to sound exposure in the mutant mice. Thus, the nociceptin system appears to participate in the regulation of the auditory system.
UR - http://www.scopus.com/inward/record.url?scp=0030983770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030983770&partnerID=8YFLogxK
U2 - 10.1093/emboj/16.8.1858
DO - 10.1093/emboj/16.8.1858
M3 - Article
C2 - 9155012
AN - SCOPUS:0030983770
VL - 16
SP - 1858
EP - 1864
JO - EMBO Journal
JF - EMBO Journal
SN - 0261-4189
IS - 8
ER -