Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor

Miyuki Nishi, Takeshi Houtani, Yukihiro Noda, Takayoshi Mamiya, Kazuo Sato, Tadashi Doi, Junko Kuno, Hiroshi Takeshima, Toshihide Nukada, Toshitaka Nabeshima, Toshio Yamashita, Tetsuo Noda, Tetsuo Sugimoto

Research output: Contribution to journalArticle

240 Citations (Scopus)

Abstract

In the G-protein-coupled receptor superfamily, the opioid receptor subfamily is constituted of the three distinct opioid receptors (namely δ-, μ- and κ-subtypes) and the receptor for nociceptin (also designated orphaninFQ). The members of the opioid receptor subfamily were known to mediate a variety of cellular inhibitory effects. The three opioid receptors are known to play central roles in mediating analgesia and many other physiological activities; however, the nociceptin receptor was identified recently and less is known about its physiological roles. Here we report the generation and characterization of mice lacking the nociceptin receptor. The knockout mice showed no significant differences in nociceptive threshold and locomotor activity compared with control mice, but they lost nociceptin-induced behavioral responses. These results indicate that the nociceptin system is not essential for regulation of nociception or locomotor activity. On the other hand, we found insufficient recovery of hearing ability from the adaptation to sound exposure in the mutant mice. Thus, the nociceptin system appears to participate in the regulation of the auditory system.

Original languageEnglish
Pages (from-to)1858-1864
Number of pages7
JournalEMBO Journal
Volume16
Issue number8
DOIs
Publication statusPublished - 15-04-1997

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Aptitude
Audition
Opioid Receptors
Hearing
Locomotion
Nociception
G-Protein-Coupled Receptors
Knockout Mice
Analgesia
Acoustic waves
Recovery
nociceptin receptor
nociceptin

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Nishi, Miyuki ; Houtani, Takeshi ; Noda, Yukihiro ; Mamiya, Takayoshi ; Sato, Kazuo ; Doi, Tadashi ; Kuno, Junko ; Takeshima, Hiroshi ; Nukada, Toshihide ; Nabeshima, Toshitaka ; Yamashita, Toshio ; Noda, Tetsuo ; Sugimoto, Tetsuo. / Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor. In: EMBO Journal. 1997 ; Vol. 16, No. 8. pp. 1858-1864.
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Nishi, M, Houtani, T, Noda, Y, Mamiya, T, Sato, K, Doi, T, Kuno, J, Takeshima, H, Nukada, T, Nabeshima, T, Yamashita, T, Noda, T & Sugimoto, T 1997, 'Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor', EMBO Journal, vol. 16, no. 8, pp. 1858-1864. https://doi.org/10.1093/emboj/16.8.1858

Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor. / Nishi, Miyuki; Houtani, Takeshi; Noda, Yukihiro; Mamiya, Takayoshi; Sato, Kazuo; Doi, Tadashi; Kuno, Junko; Takeshima, Hiroshi; Nukada, Toshihide; Nabeshima, Toshitaka; Yamashita, Toshio; Noda, Tetsuo; Sugimoto, Tetsuo.

In: EMBO Journal, Vol. 16, No. 8, 15.04.1997, p. 1858-1864.

Research output: Contribution to journalArticle

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T1 - Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor

AU - Nishi, Miyuki

AU - Houtani, Takeshi

AU - Noda, Yukihiro

AU - Mamiya, Takayoshi

AU - Sato, Kazuo

AU - Doi, Tadashi

AU - Kuno, Junko

AU - Takeshima, Hiroshi

AU - Nukada, Toshihide

AU - Nabeshima, Toshitaka

AU - Yamashita, Toshio

AU - Noda, Tetsuo

AU - Sugimoto, Tetsuo

PY - 1997/4/15

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N2 - In the G-protein-coupled receptor superfamily, the opioid receptor subfamily is constituted of the three distinct opioid receptors (namely δ-, μ- and κ-subtypes) and the receptor for nociceptin (also designated orphaninFQ). The members of the opioid receptor subfamily were known to mediate a variety of cellular inhibitory effects. The three opioid receptors are known to play central roles in mediating analgesia and many other physiological activities; however, the nociceptin receptor was identified recently and less is known about its physiological roles. Here we report the generation and characterization of mice lacking the nociceptin receptor. The knockout mice showed no significant differences in nociceptive threshold and locomotor activity compared with control mice, but they lost nociceptin-induced behavioral responses. These results indicate that the nociceptin system is not essential for regulation of nociception or locomotor activity. On the other hand, we found insufficient recovery of hearing ability from the adaptation to sound exposure in the mutant mice. Thus, the nociceptin system appears to participate in the regulation of the auditory system.

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