TY - JOUR
T1 - Unusual corneal deposit after the topical use of cyclosporine as eyedrops
AU - Kachi, Shu
AU - Hirano, Koji
AU - Takesue, Yoshiko
AU - Miura, Masanori
N1 - Funding Information:
Supported by a Grant-in-aid Scientific Research from the Ministry of Education, Japan (Hirano K: (C)11671732).
PY - 2000
Y1 - 2000
N2 - PURPOSE: To report a patient who developed bilateral corneal opacities 5 days after the beginning topical cyclosporine. METHODS: Case report. A 45-year-old woman with graft-versus-host disease presented with bilateral corneal deposits. She had been treated with topical physiological saline solution, sodium hyaluronate, ofloxacin, fluorometholone, and oxybuprocaine. Cyclosporine eyedrops were added for persistent corneal epithelial defect bilaterally. Five days after cyclosporine, she complained of visual loss and dense corneal opacities were detected that covered the pupil bilaterally. RESULTS: Deposits were also observed on the punctal plugs, and infrared spectroscopy and X-ray analysis showed that these deposits had properties of cyclosporine. CONCLUSION: Topical cyclosporine, alone or in combination with other eyedrops, may cause severe corneal deposits in patients with disturbance of the corneal epithelial barrier and decreased tear clearance. Copyright (C) 2000 Elsevier Science Inc.
AB - PURPOSE: To report a patient who developed bilateral corneal opacities 5 days after the beginning topical cyclosporine. METHODS: Case report. A 45-year-old woman with graft-versus-host disease presented with bilateral corneal deposits. She had been treated with topical physiological saline solution, sodium hyaluronate, ofloxacin, fluorometholone, and oxybuprocaine. Cyclosporine eyedrops were added for persistent corneal epithelial defect bilaterally. Five days after cyclosporine, she complained of visual loss and dense corneal opacities were detected that covered the pupil bilaterally. RESULTS: Deposits were also observed on the punctal plugs, and infrared spectroscopy and X-ray analysis showed that these deposits had properties of cyclosporine. CONCLUSION: Topical cyclosporine, alone or in combination with other eyedrops, may cause severe corneal deposits in patients with disturbance of the corneal epithelial barrier and decreased tear clearance. Copyright (C) 2000 Elsevier Science Inc.
UR - http://www.scopus.com/inward/record.url?scp=0033759921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033759921&partnerID=8YFLogxK
U2 - 10.1016/S0002-9394(00)00625-5
DO - 10.1016/S0002-9394(00)00625-5
M3 - Article
C2 - 11078849
AN - SCOPUS:0033759921
SN - 0002-9394
VL - 130
SP - 667
EP - 669
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 5
ER -