Unusual mono-reassortant of a Wa-like G1P[8] species A rotavirus containing a DS-1-like (genotype 2) NSP4 gene

Tung Phan; Tomihiko Ide; Satoshi Komoto; Pattara Khamrin; Shoko Okitsu; Koki Taniguchi; Hideaki Kikuta; Niwat Maneekarn; Satoshi Hayakawa; Hiroshi Ushijima

doi:10.1007/s11262-020-01780-2

Unusual mono-reassortant of a Wa-like G1P[8] species A rotavirus containing a DS-1-like (genotype 2) NSP4 gene

Tung Phan, Tomihiko Ide, Satoshi Komoto, Pattara Khamrin, Shoko Okitsu, Koki Taniguchi, Hideaki Kikuta, Niwat Maneekarn, Satoshi Hayakawa, Hiroshi Ushijima

Research output: Contribution to journal › Article › peer-review

Abstract

Species A rotaviruses are a major cause of acute gastroenteritis in infants and young children worldwide. Reassortment is a common phenomenon due to the segmented nature of the rotavirus genome. The complete coding sequences of a species A rotavirus strain isolated from the feces of a child with acute gastroenteritis in Japan in 2018 were determined using an unbiased viral metagenomics approach. The genetic analysis revealed that the rotavirus strain had an unusual genomic constellation (G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1), suggesting reassortment of a genotype 1 with a genotype 2 rotavirus, from which the NSP4-encoding gene was acquired.

Original language	English
Pages (from-to)	638-641
Number of pages	4
Journal	Virus Genes
Volume	56
Issue number	5
DOIs	https://doi.org/10.1007/s11262-020-01780-2
Publication status	Published - 01-10-2020

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Virology

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@article{2b59749f20924681abd5ae9ec57f3126,

title = "Unusual mono-reassortant of a Wa-like G1P[8] species A rotavirus containing a DS-1-like (genotype 2) NSP4 gene",

abstract = "Species A rotaviruses are a major cause of acute gastroenteritis in infants and young children worldwide. Reassortment is a common phenomenon due to the segmented nature of the rotavirus genome. The complete coding sequences of a species A rotavirus strain isolated from the feces of a child with acute gastroenteritis in Japan in 2018 were determined using an unbiased viral metagenomics approach. The genetic analysis revealed that the rotavirus strain had an unusual genomic constellation (G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1), suggesting reassortment of a genotype 1 with a genotype 2 rotavirus, from which the NSP4-encoding gene was acquired.",

author = "Tung Phan and Tomihiko Ide and Satoshi Komoto and Pattara Khamrin and Shoko Okitsu and Koki Taniguchi and Hideaki Kikuta and Niwat Maneekarn and Satoshi Hayakawa and Hiroshi Ushijima",

note = "Funding Information: We thank Mrs. Itoe Shiota, Mrs. Yuko Onda-Shimizu at Nihon University, School of Medicine for helping laboratory experiments, and Dr. Xianfeng Chen at Department of Health Sciences Research & Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA for analyzing the data. This work was supported by Grant-in-Aid for Scientific Research (16H05360) and Public Foundation of the Vaccination Research Center (2018-38, 2019-41). ",

year = "2020",

month = oct,

day = "1",

doi = "10.1007/s11262-020-01780-2",

language = "English",

volume = "56",

pages = "638--641",

journal = "Virus Genes",

issn = "0920-8569",

publisher = "Springer Netherlands",

number = "5",

}

Unusual mono-reassortant of a Wa-like G1P[8] species A rotavirus containing a DS-1-like (genotype 2) NSP4 gene. / Phan, Tung; Ide, Tomihiko ; Komoto, Satoshi; Khamrin, Pattara; Okitsu, Shoko; Taniguchi, Koki; Kikuta, Hideaki; Maneekarn, Niwat; Hayakawa, Satoshi; Ushijima, Hiroshi.

In: Virus Genes, Vol. 56, No. 5, 01.10.2020, p. 638-641.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Unusual mono-reassortant of a Wa-like G1P[8] species A rotavirus containing a DS-1-like (genotype 2) NSP4 gene

AU - Phan, Tung

AU - Ide, Tomihiko

AU - Komoto, Satoshi

AU - Khamrin, Pattara

AU - Okitsu, Shoko

AU - Taniguchi, Koki

AU - Kikuta, Hideaki

AU - Maneekarn, Niwat

AU - Hayakawa, Satoshi

AU - Ushijima, Hiroshi

N1 - Funding Information: We thank Mrs. Itoe Shiota, Mrs. Yuko Onda-Shimizu at Nihon University, School of Medicine for helping laboratory experiments, and Dr. Xianfeng Chen at Department of Health Sciences Research & Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA for analyzing the data. This work was supported by Grant-in-Aid for Scientific Research (16H05360) and Public Foundation of the Vaccination Research Center (2018-38, 2019-41).

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Species A rotaviruses are a major cause of acute gastroenteritis in infants and young children worldwide. Reassortment is a common phenomenon due to the segmented nature of the rotavirus genome. The complete coding sequences of a species A rotavirus strain isolated from the feces of a child with acute gastroenteritis in Japan in 2018 were determined using an unbiased viral metagenomics approach. The genetic analysis revealed that the rotavirus strain had an unusual genomic constellation (G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1), suggesting reassortment of a genotype 1 with a genotype 2 rotavirus, from which the NSP4-encoding gene was acquired.

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