Updated information on risk factors for lung cancer

Findings from the JACC study

Kenji Wakai, Masahiko Ando, Kotaro Ozasa, Yoshinori Ito, Koji Suzuki, Yoshikazu Nishino, Shin Ichi Kuriyama, Nao Seki, Takaaki Kondo, Yoshiyuki Watanabe, Yoshiyuki Ohno, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama & 20 others Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: In Japan, lung cancer is the top cause of cancer death in men and the third leading cause in women. Updated information on risk factors for lung cancer, therefore, is of great importance. The Japan Collaborative Cohort Study, a large prospective study started in 1988, has provided such information. Methods: We reviewed published findings for lung cancer from the study. The endpoint was death from this cancer. Results: The major findings were as follows. (1) The relative risks in current smokers versus nonsmokers were 4.46 in men and 3.58 in women. (2) Cigarette smoking accounted for 67.0% of lung cancer deaths in men and only 14.6% in women. (3) More than 15 years of smoking cessation may be required to decrease the risk of lung cancer to the level of never smokers. (4) A reduced risk was associated with frequent intake of green-leafy vegetables and fruit in men but not in women. These foods seemed to decrease the risk in male current or former smokers more than in female nonsmokers. (5) Serum levels of α- and β-carotenes, β-cryptoxanthin, and lycopene were inversely correlated with the risk in men. (6) In a preliminary study, serum 8-hydroxy-deoxyguanosine was higher in current smokers than in nonsmokers. Conclusions: The relative and attributable risks of smoking were smaller in Japan than in Western countries. In addition to smoking habits, therefore, we must pay attention to other risk factors for lung cancer or factors that modify the adverse effects of smoking including dietary factors.

Original languageEnglish
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 14-10-2005

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Lung Neoplasms
Smoking
Japan
Deoxyguanosine
Smoking Cessation
Carotenoids
Serum
Vegetables
Habits
Cause of Death
Fruit
Neoplasms
Cohort Studies
Prospective Studies
Food

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Wakai, Kenji ; Ando, Masahiko ; Ozasa, Kotaro ; Ito, Yoshinori ; Suzuki, Koji ; Nishino, Yoshikazu ; Kuriyama, Shin Ichi ; Seki, Nao ; Kondo, Takaaki ; Watanabe, Yoshiyuki ; Ohno, Yoshiyuki ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Toyoshima, Hideaki ; Tokudome, Shinkan ; Hashimoto, Shuji ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / Updated information on risk factors for lung cancer : Findings from the JACC study. In: Journal of epidemiology. 2005 ; Vol. 15, No. SUPPL. 2.
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abstract = "Background: In Japan, lung cancer is the top cause of cancer death in men and the third leading cause in women. Updated information on risk factors for lung cancer, therefore, is of great importance. The Japan Collaborative Cohort Study, a large prospective study started in 1988, has provided such information. Methods: We reviewed published findings for lung cancer from the study. The endpoint was death from this cancer. Results: The major findings were as follows. (1) The relative risks in current smokers versus nonsmokers were 4.46 in men and 3.58 in women. (2) Cigarette smoking accounted for 67.0{\%} of lung cancer deaths in men and only 14.6{\%} in women. (3) More than 15 years of smoking cessation may be required to decrease the risk of lung cancer to the level of never smokers. (4) A reduced risk was associated with frequent intake of green-leafy vegetables and fruit in men but not in women. These foods seemed to decrease the risk in male current or former smokers more than in female nonsmokers. (5) Serum levels of α- and β-carotenes, β-cryptoxanthin, and lycopene were inversely correlated with the risk in men. (6) In a preliminary study, serum 8-hydroxy-deoxyguanosine was higher in current smokers than in nonsmokers. Conclusions: The relative and attributable risks of smoking were smaller in Japan than in Western countries. In addition to smoking habits, therefore, we must pay attention to other risk factors for lung cancer or factors that modify the adverse effects of smoking including dietary factors.",
author = "Kenji Wakai and Masahiko Ando and Kotaro Ozasa and Yoshinori Ito and Koji Suzuki and Yoshikazu Nishino and Kuriyama, {Shin Ichi} and Nao Seki and Takaaki Kondo and Yoshiyuki Watanabe and Yoshiyuki Ohno and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Hideaki Toyoshima and Shinkan Tokudome and Shuji Hashimoto and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
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Wakai, K, Ando, M, Ozasa, K, Ito, Y, Suzuki, K, Nishino, Y, Kuriyama, SI, Seki, N, Kondo, T, Watanabe, Y, Ohno, Y, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Toyoshima, H, Tokudome, S, Hashimoto, S, Kikuchi, S, Koizumi, A, Kawamura, T, Miki, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Kitagawa, T, Kuroki, T & Tajima, K 2005, 'Updated information on risk factors for lung cancer: Findings from the JACC study', Journal of epidemiology, vol. 15, no. SUPPL. 2. https://doi.org/10.2188/jea.15.S134

Updated information on risk factors for lung cancer : Findings from the JACC study. / Wakai, Kenji; Ando, Masahiko; Ozasa, Kotaro; Ito, Yoshinori; Suzuki, Koji; Nishino, Yoshikazu; Kuriyama, Shin Ichi; Seki, Nao; Kondo, Takaaki; Watanabe, Yoshiyuki; Ohno, Yoshiyuki; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Toyoshima, Hideaki; Tokudome, Shinkan; Hashimoto, Shuji; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

In: Journal of epidemiology, Vol. 15, No. SUPPL. 2, 14.10.2005.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Updated information on risk factors for lung cancer

T2 - Findings from the JACC study

AU - Wakai, Kenji

AU - Ando, Masahiko

AU - Ozasa, Kotaro

AU - Ito, Yoshinori

AU - Suzuki, Koji

AU - Nishino, Yoshikazu

AU - Kuriyama, Shin Ichi

AU - Seki, Nao

AU - Kondo, Takaaki

AU - Watanabe, Yoshiyuki

AU - Ohno, Yoshiyuki

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Toyoshima, Hideaki

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2005/10/14

Y1 - 2005/10/14

N2 - Background: In Japan, lung cancer is the top cause of cancer death in men and the third leading cause in women. Updated information on risk factors for lung cancer, therefore, is of great importance. The Japan Collaborative Cohort Study, a large prospective study started in 1988, has provided such information. Methods: We reviewed published findings for lung cancer from the study. The endpoint was death from this cancer. Results: The major findings were as follows. (1) The relative risks in current smokers versus nonsmokers were 4.46 in men and 3.58 in women. (2) Cigarette smoking accounted for 67.0% of lung cancer deaths in men and only 14.6% in women. (3) More than 15 years of smoking cessation may be required to decrease the risk of lung cancer to the level of never smokers. (4) A reduced risk was associated with frequent intake of green-leafy vegetables and fruit in men but not in women. These foods seemed to decrease the risk in male current or former smokers more than in female nonsmokers. (5) Serum levels of α- and β-carotenes, β-cryptoxanthin, and lycopene were inversely correlated with the risk in men. (6) In a preliminary study, serum 8-hydroxy-deoxyguanosine was higher in current smokers than in nonsmokers. Conclusions: The relative and attributable risks of smoking were smaller in Japan than in Western countries. In addition to smoking habits, therefore, we must pay attention to other risk factors for lung cancer or factors that modify the adverse effects of smoking including dietary factors.

AB - Background: In Japan, lung cancer is the top cause of cancer death in men and the third leading cause in women. Updated information on risk factors for lung cancer, therefore, is of great importance. The Japan Collaborative Cohort Study, a large prospective study started in 1988, has provided such information. Methods: We reviewed published findings for lung cancer from the study. The endpoint was death from this cancer. Results: The major findings were as follows. (1) The relative risks in current smokers versus nonsmokers were 4.46 in men and 3.58 in women. (2) Cigarette smoking accounted for 67.0% of lung cancer deaths in men and only 14.6% in women. (3) More than 15 years of smoking cessation may be required to decrease the risk of lung cancer to the level of never smokers. (4) A reduced risk was associated with frequent intake of green-leafy vegetables and fruit in men but not in women. These foods seemed to decrease the risk in male current or former smokers more than in female nonsmokers. (5) Serum levels of α- and β-carotenes, β-cryptoxanthin, and lycopene were inversely correlated with the risk in men. (6) In a preliminary study, serum 8-hydroxy-deoxyguanosine was higher in current smokers than in nonsmokers. Conclusions: The relative and attributable risks of smoking were smaller in Japan than in Western countries. In addition to smoking habits, therefore, we must pay attention to other risk factors for lung cancer or factors that modify the adverse effects of smoking including dietary factors.

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DO - 10.2188/jea.15.S134

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JO - Journal of Epidemiology

JF - Journal of Epidemiology

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