Uric acid and left ventricular hypertrophy in Japanese men

Hirotsugu Mitsuhashi, Hiroshi Yatsuya, Kunihiro Matsushita, Huiming Zhang, Rei Otsuka, Takashi Muramatsu, Seiko Takefuji, Yo Hotta, Takahisa Kondo, Toyoaki Murohara, Hideaki Toyoshima, Koji Tamakoshi

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Experimental studies have reported that allopurinol protects hypertensive rats from left ventricular hypertrophy (LVH) with negligible effects on blood pressure (BP). Uric acid (UA) was thought to induce cardiomyocyte growth and interstitial fibrosis of the heart, partly via activation of the renin-angiotensin system. In the present study, the relationship between serum UA levels and electrocardiographically-diagnosed LVH (ECG-LVH) was examined in Japanese men not taking medication for hypertension (HTN), which could confound the association. Methods and Results: A total of 3,305 male workers aged 35-66 years (mean age±SD, 48.0±7.1) were studied. LVH was defined as meeting the ECG criteria (ie, Sokolow-Lyon voltage and/or Cornell voltage QRS duration product). Subjects were divided into 3 groups by tertile of serum UA level. The highest tertile (UA range 0.39-0.65 mmol/L or 6.6-11.0 mg/dl) had a significantly increased prevalence of LVH compared with the lowest tertile independent of age, body mass index, serum creatinine level, HTN, diabetes and hyperlipidemia (odds ratio 1.58, 95% confidence interval 1.23-2.02, P<0.001). Similar results were obtained in both the normal and high BP subgroups. Conclusions: UA concentration independently and positively associated with ECG-LVH in Japanese men.

Original languageEnglish
Pages (from-to)667-672
Number of pages6
JournalCirculation Journal
Volume73
Issue number4
DOIs
Publication statusPublished - 01-04-2009
Externally publishedYes

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Left Ventricular Hypertrophy
Uric Acid
Hypertension
Serum
Allopurinol
Renin-Angiotensin System
Hyperlipidemias
Cardiac Myocytes
Creatinine
Electrocardiography
Body Mass Index
Fibrosis
Odds Ratio
Confidence Intervals
Blood Pressure
Growth

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Mitsuhashi, H., Yatsuya, H., Matsushita, K., Zhang, H., Otsuka, R., Muramatsu, T., ... Tamakoshi, K. (2009). Uric acid and left ventricular hypertrophy in Japanese men. Circulation Journal, 73(4), 667-672. https://doi.org/10.1253/circj.CJ-08-0626
Mitsuhashi, Hirotsugu ; Yatsuya, Hiroshi ; Matsushita, Kunihiro ; Zhang, Huiming ; Otsuka, Rei ; Muramatsu, Takashi ; Takefuji, Seiko ; Hotta, Yo ; Kondo, Takahisa ; Murohara, Toyoaki ; Toyoshima, Hideaki ; Tamakoshi, Koji. / Uric acid and left ventricular hypertrophy in Japanese men. In: Circulation Journal. 2009 ; Vol. 73, No. 4. pp. 667-672.
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abstract = "Background: Experimental studies have reported that allopurinol protects hypertensive rats from left ventricular hypertrophy (LVH) with negligible effects on blood pressure (BP). Uric acid (UA) was thought to induce cardiomyocyte growth and interstitial fibrosis of the heart, partly via activation of the renin-angiotensin system. In the present study, the relationship between serum UA levels and electrocardiographically-diagnosed LVH (ECG-LVH) was examined in Japanese men not taking medication for hypertension (HTN), which could confound the association. Methods and Results: A total of 3,305 male workers aged 35-66 years (mean age±SD, 48.0±7.1) were studied. LVH was defined as meeting the ECG criteria (ie, Sokolow-Lyon voltage and/or Cornell voltage QRS duration product). Subjects were divided into 3 groups by tertile of serum UA level. The highest tertile (UA range 0.39-0.65 mmol/L or 6.6-11.0 mg/dl) had a significantly increased prevalence of LVH compared with the lowest tertile independent of age, body mass index, serum creatinine level, HTN, diabetes and hyperlipidemia (odds ratio 1.58, 95{\%} confidence interval 1.23-2.02, P<0.001). Similar results were obtained in both the normal and high BP subgroups. Conclusions: UA concentration independently and positively associated with ECG-LVH in Japanese men.",
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Mitsuhashi, H, Yatsuya, H, Matsushita, K, Zhang, H, Otsuka, R, Muramatsu, T, Takefuji, S, Hotta, Y, Kondo, T, Murohara, T, Toyoshima, H & Tamakoshi, K 2009, 'Uric acid and left ventricular hypertrophy in Japanese men', Circulation Journal, vol. 73, no. 4, pp. 667-672. https://doi.org/10.1253/circj.CJ-08-0626

Uric acid and left ventricular hypertrophy in Japanese men. / Mitsuhashi, Hirotsugu; Yatsuya, Hiroshi; Matsushita, Kunihiro; Zhang, Huiming; Otsuka, Rei; Muramatsu, Takashi; Takefuji, Seiko; Hotta, Yo; Kondo, Takahisa; Murohara, Toyoaki; Toyoshima, Hideaki; Tamakoshi, Koji.

In: Circulation Journal, Vol. 73, No. 4, 01.04.2009, p. 667-672.

Research output: Contribution to journalArticle

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T1 - Uric acid and left ventricular hypertrophy in Japanese men

AU - Mitsuhashi, Hirotsugu

AU - Yatsuya, Hiroshi

AU - Matsushita, Kunihiro

AU - Zhang, Huiming

AU - Otsuka, Rei

AU - Muramatsu, Takashi

AU - Takefuji, Seiko

AU - Hotta, Yo

AU - Kondo, Takahisa

AU - Murohara, Toyoaki

AU - Toyoshima, Hideaki

AU - Tamakoshi, Koji

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Y1 - 2009/4/1

N2 - Background: Experimental studies have reported that allopurinol protects hypertensive rats from left ventricular hypertrophy (LVH) with negligible effects on blood pressure (BP). Uric acid (UA) was thought to induce cardiomyocyte growth and interstitial fibrosis of the heart, partly via activation of the renin-angiotensin system. In the present study, the relationship between serum UA levels and electrocardiographically-diagnosed LVH (ECG-LVH) was examined in Japanese men not taking medication for hypertension (HTN), which could confound the association. Methods and Results: A total of 3,305 male workers aged 35-66 years (mean age±SD, 48.0±7.1) were studied. LVH was defined as meeting the ECG criteria (ie, Sokolow-Lyon voltage and/or Cornell voltage QRS duration product). Subjects were divided into 3 groups by tertile of serum UA level. The highest tertile (UA range 0.39-0.65 mmol/L or 6.6-11.0 mg/dl) had a significantly increased prevalence of LVH compared with the lowest tertile independent of age, body mass index, serum creatinine level, HTN, diabetes and hyperlipidemia (odds ratio 1.58, 95% confidence interval 1.23-2.02, P<0.001). Similar results were obtained in both the normal and high BP subgroups. Conclusions: UA concentration independently and positively associated with ECG-LVH in Japanese men.

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Mitsuhashi H, Yatsuya H, Matsushita K, Zhang H, Otsuka R, Muramatsu T et al. Uric acid and left ventricular hypertrophy in Japanese men. Circulation Journal. 2009 Apr 1;73(4):667-672. https://doi.org/10.1253/circj.CJ-08-0626