Uric acid distribution volume calculated by kinetic modeling and extracellular volume predicted by bioimpedance method

Toru Shinzato, Shigeru Nakai, Takahito Ito, Kazuhiko Shibata, Teppei Matsuoka, Shinya Kato, Takeshi Aoki, Ikuto Masakane, Hiroki Hayashi, Naotake Tsuboi, Midori Hasegawa, Daijo Inaguma, Yukio Yuzawa, Susumu Ookawara

Research output: Contribution to journalArticle

Abstract

Background: Several reports indicate that extracellular volume predicted by bioimpedance analysis method is associated with hydration status of hemodialysis patients. Theory: Fundamentally, uric acid does not cross cell membranes by simple diffusion, either by facilitated diffusion or by active transport. In addition, uric acid cannot move through cell membranes in most tissues other than those involved in uric acid excretion. These facts support the interpretation that uric acid distribution volume would therefore correlate with extracellular volume. Methods: We examined correlation between uric acid distribution volume calculated by uric acid mass-balance modeling from regular blood test results and extracellular volume predicted by bioimpedance analysis predicted by BCM (Fresenius Medical Care) in 53 patients. Results: There was a significant correlation between uric acid distribution volume (x) and extracellular volume predicted by bioimpedance analysis (y): y = 0.69x + 3.39, r2 = 0.61, p < 0.0001. Bland–Altman analysis showed systematic error for uric acid distribution volume versus extracellular volume predicted by bioimpedance analysis (mean difference between uric acid distribution volume and extracellular volume predicted by bioimpedance analysis was 0.94 L, 95% confidence interval of difference was −3.29 to 5.17 L). Conclusion: Uric acid distribution volume calculated by uric acid mass-balance modeling from regular blood test results may be an alternative marker of extracellular volume predicted by bioimpedance analysis.

Original languageEnglish
Pages (from-to)701-709
Number of pages9
JournalInternational Journal of Artificial Organs
Volume43
Issue number11
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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