TY - JOUR
T1 - Urinary and circulating levels of the anti-angiogenic isoform of vascular endothelial growth factor-A in patients with chronic kidney disease
AU - Kikuchi, Ryosuke
AU - Yasuda, Yoshinari
AU - Nakatochi, Masahiro
AU - Shibata, Yohei
AU - Hara, Toshiaki
AU - Suzuki, Atsuo
AU - Imaizumi, Takahiro
AU - Suzuki, Susumu
AU - Ishii, Hideki
AU - Takeshita, Kyosuke
AU - Matsushita, Tadashi
AU - Maruyama, Shoichi
AU - Murohara, Toyoaki
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/12
Y1 - 2017/12
N2 - Introduction The protective effects of vascular endothelial growth factor (VEGF)-A165b on kidney tissue have been suggested in animal studies. However, the relevance of urinary and circulating VEGF-A165b levels in chronic kidney disease patients remains unclear. Therefore, the present study aimed to investigate the urinary and circulating VEGF-A165b levels in patients with chronic kidney disease. Methods This observational study enrolled a total of 92 Japanese patients with chronic kidney disease, who had undergone inulin renal clearance measurements for the accurate assessment of measured GFR. Urinary or circulating total VEGF-A and VEGF-A165b levels were measured using enzyme-linked immunosorbent assay. Results Urinary VEGF-A165b levels were significantly lower in G3a, G3b, and G4 + G5 category patients than in G1 + G2 category patients. Correlation analysis found that serum creatinine levels, serum cystatin C levels, eGFRcre, eGFRcys, and mGFR were weakly but significantly correlated with urinary VEGF-A165b levels. Additionally, circulating VEGF-A165b levels were significantly higher in G4 + G5 category patients than in G1 + G2 category patients. Conclusion A low urinary VEGF-A165b level reflects renal dysfunction in the chronic kidney disease stage, while a high circulating VEGF-A165b level cannot be attributed to decreased renal clearance.
AB - Introduction The protective effects of vascular endothelial growth factor (VEGF)-A165b on kidney tissue have been suggested in animal studies. However, the relevance of urinary and circulating VEGF-A165b levels in chronic kidney disease patients remains unclear. Therefore, the present study aimed to investigate the urinary and circulating VEGF-A165b levels in patients with chronic kidney disease. Methods This observational study enrolled a total of 92 Japanese patients with chronic kidney disease, who had undergone inulin renal clearance measurements for the accurate assessment of measured GFR. Urinary or circulating total VEGF-A and VEGF-A165b levels were measured using enzyme-linked immunosorbent assay. Results Urinary VEGF-A165b levels were significantly lower in G3a, G3b, and G4 + G5 category patients than in G1 + G2 category patients. Correlation analysis found that serum creatinine levels, serum cystatin C levels, eGFRcre, eGFRcys, and mGFR were weakly but significantly correlated with urinary VEGF-A165b levels. Additionally, circulating VEGF-A165b levels were significantly higher in G4 + G5 category patients than in G1 + G2 category patients. Conclusion A low urinary VEGF-A165b level reflects renal dysfunction in the chronic kidney disease stage, while a high circulating VEGF-A165b level cannot be attributed to decreased renal clearance.
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U2 - 10.1016/j.cca.2017.10.014
DO - 10.1016/j.cca.2017.10.014
M3 - Article
C2 - 29055691
AN - SCOPUS:85032226573
SN - 0009-8981
VL - 475
SP - 102
EP - 108
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -