Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan

Jun Ueyama, Akiko Kimata, Michihiro Kamijima, Nobuyuki Hamajima, Yoshinori Ito, Koji Suzuki, Takashi Inoue, Kanami Yamamoto, Kenji Takagi, Isao Saito, Ken ichi Miyamoto, Takaaki Hasegawa, Takaaki Kondo

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Limited data are available on the background levels of exposure to synthetic pyrethroid (PYR) in Japan, despite their frequent application for agriculture and indoor extermination and possible effects of chronic and/or low-dose PYR exposure on human health. This study was conducted to describe the level and distribution of one of the major PYR metabolites, 3-phenoxybenzoic acid (3-PBA), in urine samples collected from a general population in Japan. The subjects were 535 individuals (184 men and 351 women; 61.5±9.8 years of age, mean±S.D.) residing in a town in Hokkaido, a dairy and agricultural area. Urinary 3-PBA was found detectable in 98% of samples above the limit of detection of 0.02 μg/l. The geometric mean values of urinary 3-PBA in occupationally exposed farmers (n=87) and the remaining general group without occupational exposure (n=448) were 0.38 and 0.29 μg/l, respectively, ranging from <LOD to 17.09 μg/l. No significant differences in urinary 3-PBA concentrations were shown between these two groups. Moreover, 3-PBA concentrations were found comparable to those reported in some countries. The present study is, to our knowledge, the first report of a biological monitoring study of urinary 3-PBA, which elucidated the background environmental exposure level of PYR in the Japanese general population without occupational exposure. Further nationwide studies covering different seasons and age distribution are needed to monitor the urinary 3-PBA levels in Japan.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalEnvironmental Research
Volume109
Issue number2
DOIs
Publication statusPublished - 01-02-2009

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excretion
Japan
Pyrethrins
pyrethroid
acid
Population
occupational exposure
Occupational Exposure
Dairies
Environmental Monitoring
Age Distribution
Environmental Exposure
background level
Metabolites
3-phenoxybenzoic acid
Agriculture
age structure
urine
Limit of Detection
metabolite

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Environmental Science(all)

Cite this

Ueyama, Jun ; Kimata, Akiko ; Kamijima, Michihiro ; Hamajima, Nobuyuki ; Ito, Yoshinori ; Suzuki, Koji ; Inoue, Takashi ; Yamamoto, Kanami ; Takagi, Kenji ; Saito, Isao ; Miyamoto, Ken ichi ; Hasegawa, Takaaki ; Kondo, Takaaki. / Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan. In: Environmental Research. 2009 ; Vol. 109, No. 2. pp. 175-180.
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abstract = "Limited data are available on the background levels of exposure to synthetic pyrethroid (PYR) in Japan, despite their frequent application for agriculture and indoor extermination and possible effects of chronic and/or low-dose PYR exposure on human health. This study was conducted to describe the level and distribution of one of the major PYR metabolites, 3-phenoxybenzoic acid (3-PBA), in urine samples collected from a general population in Japan. The subjects were 535 individuals (184 men and 351 women; 61.5±9.8 years of age, mean±S.D.) residing in a town in Hokkaido, a dairy and agricultural area. Urinary 3-PBA was found detectable in 98{\%} of samples above the limit of detection of 0.02 μg/l. The geometric mean values of urinary 3-PBA in occupationally exposed farmers (n=87) and the remaining general group without occupational exposure (n=448) were 0.38 and 0.29 μg/l, respectively, ranging from <LOD to 17.09 μg/l. No significant differences in urinary 3-PBA concentrations were shown between these two groups. Moreover, 3-PBA concentrations were found comparable to those reported in some countries. The present study is, to our knowledge, the first report of a biological monitoring study of urinary 3-PBA, which elucidated the background environmental exposure level of PYR in the Japanese general population without occupational exposure. Further nationwide studies covering different seasons and age distribution are needed to monitor the urinary 3-PBA levels in Japan.",
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Ueyama, J, Kimata, A, Kamijima, M, Hamajima, N, Ito, Y, Suzuki, K, Inoue, T, Yamamoto, K, Takagi, K, Saito, I, Miyamoto, KI, Hasegawa, T & Kondo, T 2009, 'Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan', Environmental Research, vol. 109, no. 2, pp. 175-180. https://doi.org/10.1016/j.envres.2008.09.006

Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan. / Ueyama, Jun; Kimata, Akiko; Kamijima, Michihiro; Hamajima, Nobuyuki; Ito, Yoshinori; Suzuki, Koji; Inoue, Takashi; Yamamoto, Kanami; Takagi, Kenji; Saito, Isao; Miyamoto, Ken ichi; Hasegawa, Takaaki; Kondo, Takaaki.

In: Environmental Research, Vol. 109, No. 2, 01.02.2009, p. 175-180.

Research output: Contribution to journalArticle

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T1 - Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan

AU - Ueyama, Jun

AU - Kimata, Akiko

AU - Kamijima, Michihiro

AU - Hamajima, Nobuyuki

AU - Ito, Yoshinori

AU - Suzuki, Koji

AU - Inoue, Takashi

AU - Yamamoto, Kanami

AU - Takagi, Kenji

AU - Saito, Isao

AU - Miyamoto, Ken ichi

AU - Hasegawa, Takaaki

AU - Kondo, Takaaki

PY - 2009/2/1

Y1 - 2009/2/1

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