Urinary protein to creatinine ratio and urinary sediments are useful for the screening of chronic kidney disease

Saori Kobayashi, Masato Hoshi, Isao Inagaki, Takayuki Hattori, Seiko Ushimaru, Hazuki Ohashi, Nobuyuki Furuta, Masao Marumoto, Masao Takemura, Hiroyasu Ito, Mitsuru Seishima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chronic Kidney Disease (CKD) is an important risk factor of the End Stage Renal Disease (ESRD). In this study, we investigated whether the protein to creatinine ratio (the ratio of P/C) determined by the semiquantitative urinary stick test and urinary sediments are useful for the early detection of CKD. One hundred sixty patients were classified to four or five groups by P/C ratio and various biochemical markers were analyzed. As a result, the 300 mg/g x Cr of P/C group showed a significantly increased serum cystatin C level. The positive rate of the P/C ratio in CKD stage was significantly increased compared with the conventional protein qualitative analysis. Further, the amounts of urinary sediments in CKD stage 1 to 2 were increased, such as hyaline cast, and pathological casts were increased in CKD stage 3 to 5. Thus, our present study suggests that the ratio of P/C and urinary sediments are useful for the screening of CKD.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalRinsho byori. The Japanese journal of clinical pathology
Volume57
Issue number3
Publication statusPublished - 03-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'Urinary protein to creatinine ratio and urinary sediments are useful for the screening of chronic kidney disease'. Together they form a unique fingerprint.

  • Cite this

    Kobayashi, S., Hoshi, M., Inagaki, I., Hattori, T., Ushimaru, S., Ohashi, H., Furuta, N., Marumoto, M., Takemura, M., Ito, H., & Seishima, M. (2009). Urinary protein to creatinine ratio and urinary sediments are useful for the screening of chronic kidney disease. Rinsho byori. The Japanese journal of clinical pathology, 57(3), 213-220.