Usage of gastric antisecretory drugs in palliative care of lung cancer patients

Sumiyo Tanaka, Haruka Kotani, Masayuki Miyazaki, Aya Hirabayashi, Chihiro Murosaki, Kaori Yamashita, Rina Kishi, Akihiro Mouri, Masashi Kondo, Kaoru Shimokata, Yoshinori Hasegawa, Kiyofumi Yamada, Yukihiro Noda

Research output: Contribution to journalArticlepeer-review


Non-steroidal anti-inflammatory drugs (NSAID) and steroids are important drugs that are the most frequently prescribed medications for the relief of cancer pain. However, there is overwhelming evidence that these drugs cause various forms of gastric mucosal injury. Based on clinical experience, gastric antisecretory drugs such as the proton pump inhibitor (PPI) and the histamine-H 2 receptor antagonist (H 2RA) are widely used to avoid the gastrointestinal problems caused by NSAID and steroids. There are individual differences in how physicians use PPI and H 2RA. In the present study, we retrospectively examined PPI and H 2RA usage in the palliative care of 83 lung cancer patients, who were routinely prescribed an NSAID alone (single group) or a combination of an NSAID with a steroid (combination group). We also administered a questionnaire survey to 25 prescribing physicians specializing in respiratory medicine. The proportion of physicians prescribing a PPI prophylactically in the combination group was significantly higher than that of the single group. According to answers in the questionnaire survey, PPI prescribed by physicians in the single group was determined by the performance status and history of gastrointestinal problems in patients. Regardless of such factors, in the combination group, PPI was deliberately prescribed with steroids. Further investigation is needed to examine the clinical effects of PPI in palliative care, so as to establish more appropriate use of both PPI and H 2RA.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalJapanese Journal of Cancer and Chemotherapy
Issue number2
Publication statusPublished - 02-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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