TY - JOUR
T1 - Usage of gastric antisecretory drugs in palliative care of lung cancer patients
AU - Tanaka, Sumiyo
AU - Kotani, Haruka
AU - Miyazaki, Masayuki
AU - Hirabayashi, Aya
AU - Murosaki, Chihiro
AU - Yamashita, Kaori
AU - Kishi, Rina
AU - Mouri, Akihiro
AU - Kondo, Masashi
AU - Shimokata, Kaoru
AU - Hasegawa, Yoshinori
AU - Yamada, Kiyofumi
AU - Noda, Yukihiro
PY - 2012/2
Y1 - 2012/2
N2 - Non-steroidal anti-inflammatory drugs (NSAID) and steroids are important drugs that are the most frequently prescribed medications for the relief of cancer pain. However, there is overwhelming evidence that these drugs cause various forms of gastric mucosal injury. Based on clinical experience, gastric antisecretory drugs such as the proton pump inhibitor (PPI) and the histamine-H 2 receptor antagonist (H 2RA) are widely used to avoid the gastrointestinal problems caused by NSAID and steroids. There are individual differences in how physicians use PPI and H 2RA. In the present study, we retrospectively examined PPI and H 2RA usage in the palliative care of 83 lung cancer patients, who were routinely prescribed an NSAID alone (single group) or a combination of an NSAID with a steroid (combination group). We also administered a questionnaire survey to 25 prescribing physicians specializing in respiratory medicine. The proportion of physicians prescribing a PPI prophylactically in the combination group was significantly higher than that of the single group. According to answers in the questionnaire survey, PPI prescribed by physicians in the single group was determined by the performance status and history of gastrointestinal problems in patients. Regardless of such factors, in the combination group, PPI was deliberately prescribed with steroids. Further investigation is needed to examine the clinical effects of PPI in palliative care, so as to establish more appropriate use of both PPI and H 2RA.
AB - Non-steroidal anti-inflammatory drugs (NSAID) and steroids are important drugs that are the most frequently prescribed medications for the relief of cancer pain. However, there is overwhelming evidence that these drugs cause various forms of gastric mucosal injury. Based on clinical experience, gastric antisecretory drugs such as the proton pump inhibitor (PPI) and the histamine-H 2 receptor antagonist (H 2RA) are widely used to avoid the gastrointestinal problems caused by NSAID and steroids. There are individual differences in how physicians use PPI and H 2RA. In the present study, we retrospectively examined PPI and H 2RA usage in the palliative care of 83 lung cancer patients, who were routinely prescribed an NSAID alone (single group) or a combination of an NSAID with a steroid (combination group). We also administered a questionnaire survey to 25 prescribing physicians specializing in respiratory medicine. The proportion of physicians prescribing a PPI prophylactically in the combination group was significantly higher than that of the single group. According to answers in the questionnaire survey, PPI prescribed by physicians in the single group was determined by the performance status and history of gastrointestinal problems in patients. Regardless of such factors, in the combination group, PPI was deliberately prescribed with steroids. Further investigation is needed to examine the clinical effects of PPI in palliative care, so as to establish more appropriate use of both PPI and H 2RA.
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M3 - Article
C2 - 22333637
AN - SCOPUS:84860526591
SN - 0385-0684
VL - 39
SP - 251
EP - 256
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
IS - 2
ER -
