Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: Comparison with rapid troponin T and myoglobin tests

Yoshihiko Seino, Ken ichi Ogata, Teruo Takano, Junichi Ishii, Hitoshi Hishida, Hiroshi Morita, Hitoshi Takeshita, Yasushi Takagi, Hiroshi Sugiyama, Takao Tanaka, Yasushi Kitaura

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Abstract

PURPOSE: We sought to determine the clinical utility of a newly developed qualitative test to measure heart-type fatty acid-binding protein levels in blood for the early identification of myocardial infarction. METHODS: We measured heart-type fatty acid-binding protein levels in 371 consecutive patients with acute chest pain and suspected myocardial infarction, and compared the performance of this test with those of troponin T and myoglobin tests. Levels of heart-type fatty acid-binding protein ≥6.2 ng/mL were considered as positive results. RESULTS: A final diagnosis of acute myocardial infarction was made in 181 patients (49%). Of the 68 patients who presented within 2 hours of the onset of symptoms, 37 (54%) had a final diagnosis of myocardial infarction. The sensitivity of the rapid heart-type fatty acid-binding protein test was 89% (33/37), significantly higher than for troponin T (22% [8/37]; P<0.001) and myoglobin (38% [14/37]; P<0.001). However, the specificity of troponin T (94% [29/31]) was significantly better than for heart-type fatty acid-binding protein (52% [16/31]; P= 0.002) within 2 hours. The area under the receiver operating characteristic curve for heart-type fatty acid-binding protein levels was greater than that for myoglobin (0.72 vs. 0.61, P = 0.01) among patients who presented within 2 hours. CONCLUSION: A novel whole blood rapid heart-type fatty acid-binding protein test can be useful in the early evaluation of patients who present with acute chest pain.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalAmerican Journal of Medicine
Volume115
Issue number3
DOIs
Publication statusPublished - 15-08-2003

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Fatty Acid-Binding Proteins
Troponin T
Myoglobin
Acute Pain
Chest Pain
Myocardial Infarction
ROC Curve

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Seino, Yoshihiko ; Ogata, Ken ichi ; Takano, Teruo ; Ishii, Junichi ; Hishida, Hitoshi ; Morita, Hiroshi ; Takeshita, Hitoshi ; Takagi, Yasushi ; Sugiyama, Hiroshi ; Tanaka, Takao ; Kitaura, Yasushi. / Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain : Comparison with rapid troponin T and myoglobin tests. In: American Journal of Medicine. 2003 ; Vol. 115, No. 3. pp. 185-190.
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abstract = "PURPOSE: We sought to determine the clinical utility of a newly developed qualitative test to measure heart-type fatty acid-binding protein levels in blood for the early identification of myocardial infarction. METHODS: We measured heart-type fatty acid-binding protein levels in 371 consecutive patients with acute chest pain and suspected myocardial infarction, and compared the performance of this test with those of troponin T and myoglobin tests. Levels of heart-type fatty acid-binding protein ≥6.2 ng/mL were considered as positive results. RESULTS: A final diagnosis of acute myocardial infarction was made in 181 patients (49{\%}). Of the 68 patients who presented within 2 hours of the onset of symptoms, 37 (54{\%}) had a final diagnosis of myocardial infarction. The sensitivity of the rapid heart-type fatty acid-binding protein test was 89{\%} (33/37), significantly higher than for troponin T (22{\%} [8/37]; P<0.001) and myoglobin (38{\%} [14/37]; P<0.001). However, the specificity of troponin T (94{\%} [29/31]) was significantly better than for heart-type fatty acid-binding protein (52{\%} [16/31]; P= 0.002) within 2 hours. The area under the receiver operating characteristic curve for heart-type fatty acid-binding protein levels was greater than that for myoglobin (0.72 vs. 0.61, P = 0.01) among patients who presented within 2 hours. CONCLUSION: A novel whole blood rapid heart-type fatty acid-binding protein test can be useful in the early evaluation of patients who present with acute chest pain.",
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Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain : Comparison with rapid troponin T and myoglobin tests. / Seino, Yoshihiko; Ogata, Ken ichi; Takano, Teruo; Ishii, Junichi; Hishida, Hitoshi; Morita, Hiroshi; Takeshita, Hitoshi; Takagi, Yasushi; Sugiyama, Hiroshi; Tanaka, Takao; Kitaura, Yasushi.

In: American Journal of Medicine, Vol. 115, No. 3, 15.08.2003, p. 185-190.

Research output: Contribution to journalArticle

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T1 - Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain

T2 - Comparison with rapid troponin T and myoglobin tests

AU - Seino, Yoshihiko

AU - Ogata, Ken ichi

AU - Takano, Teruo

AU - Ishii, Junichi

AU - Hishida, Hitoshi

AU - Morita, Hiroshi

AU - Takeshita, Hitoshi

AU - Takagi, Yasushi

AU - Sugiyama, Hiroshi

AU - Tanaka, Takao

AU - Kitaura, Yasushi

PY - 2003/8/15

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N2 - PURPOSE: We sought to determine the clinical utility of a newly developed qualitative test to measure heart-type fatty acid-binding protein levels in blood for the early identification of myocardial infarction. METHODS: We measured heart-type fatty acid-binding protein levels in 371 consecutive patients with acute chest pain and suspected myocardial infarction, and compared the performance of this test with those of troponin T and myoglobin tests. Levels of heart-type fatty acid-binding protein ≥6.2 ng/mL were considered as positive results. RESULTS: A final diagnosis of acute myocardial infarction was made in 181 patients (49%). Of the 68 patients who presented within 2 hours of the onset of symptoms, 37 (54%) had a final diagnosis of myocardial infarction. The sensitivity of the rapid heart-type fatty acid-binding protein test was 89% (33/37), significantly higher than for troponin T (22% [8/37]; P<0.001) and myoglobin (38% [14/37]; P<0.001). However, the specificity of troponin T (94% [29/31]) was significantly better than for heart-type fatty acid-binding protein (52% [16/31]; P= 0.002) within 2 hours. The area under the receiver operating characteristic curve for heart-type fatty acid-binding protein levels was greater than that for myoglobin (0.72 vs. 0.61, P = 0.01) among patients who presented within 2 hours. CONCLUSION: A novel whole blood rapid heart-type fatty acid-binding protein test can be useful in the early evaluation of patients who present with acute chest pain.

AB - PURPOSE: We sought to determine the clinical utility of a newly developed qualitative test to measure heart-type fatty acid-binding protein levels in blood for the early identification of myocardial infarction. METHODS: We measured heart-type fatty acid-binding protein levels in 371 consecutive patients with acute chest pain and suspected myocardial infarction, and compared the performance of this test with those of troponin T and myoglobin tests. Levels of heart-type fatty acid-binding protein ≥6.2 ng/mL were considered as positive results. RESULTS: A final diagnosis of acute myocardial infarction was made in 181 patients (49%). Of the 68 patients who presented within 2 hours of the onset of symptoms, 37 (54%) had a final diagnosis of myocardial infarction. The sensitivity of the rapid heart-type fatty acid-binding protein test was 89% (33/37), significantly higher than for troponin T (22% [8/37]; P<0.001) and myoglobin (38% [14/37]; P<0.001). However, the specificity of troponin T (94% [29/31]) was significantly better than for heart-type fatty acid-binding protein (52% [16/31]; P= 0.002) within 2 hours. The area under the receiver operating characteristic curve for heart-type fatty acid-binding protein levels was greater than that for myoglobin (0.72 vs. 0.61, P = 0.01) among patients who presented within 2 hours. CONCLUSION: A novel whole blood rapid heart-type fatty acid-binding protein test can be useful in the early evaluation of patients who present with acute chest pain.

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