TY - JOUR
T1 - Usefulness of combining 123I-FP-CIT-SPECT striatal asymmetry index and cardiac 123I-metaiodobenzylguanidine scintigraphy examinations for diagnosis of parkinsonisms
AU - Niimi, Yoshiki
AU - Ito, Shinji
AU - Murate, Kenichiro
AU - Hirota, Seiko
AU - Hikichi, Chika
AU - Ishikawa, Tomomasa
AU - Maeda, Toshiki
AU - Nagao, Ryunosuke
AU - Shima, Sayuri
AU - Mizutani, Yasuaki
AU - Ueda, Akihiro
AU - Mutoh, Tatsuro
N1 - Funding Information:
The authors thank Drs. Madoka Kizawa for her assistance in evaluating some patients. This work was supported in part by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology (16k09685) of Japan, and Research Grants for Intractable Diseases from the Ministry of Health, Labour and Welfare (16ek0109056h003) of Japan to T.M.
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/6/15
Y1 - 2017/6/15
N2 - Background Although single-photon emission computerized tomography of the dopamine transporter (DAT-SPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown. Methods We enrolled 32 patients showing parkinsonism with normal cardiac 123I-metaiodobenzylguanidine (MIBG) uptake and abnormal DAT-SPECT findings among 84 consecutive patients with parkinsonism. We divided these patients into two groups (group 1: Parkinson's disease, group 2: corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy), and compared their clinical characteristics, specific binding ratios, and striatal asymmetry indexes on DAT-SPECT examinations. Results The striatal asymmetry indexes were significantly lower in group 1 than in group 2 (p < 0.05), but there were no differences in the specific binding ratios between the two groups. Conclusion The combined use of striatal asymmetry index on DAT-SPECT and cardiac MIBG scintigraphy might offer useful clues for the differential diagnosis of the early phase Parkinson's disease from other parkinsonian syndromes.
AB - Background Although single-photon emission computerized tomography of the dopamine transporter (DAT-SPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown. Methods We enrolled 32 patients showing parkinsonism with normal cardiac 123I-metaiodobenzylguanidine (MIBG) uptake and abnormal DAT-SPECT findings among 84 consecutive patients with parkinsonism. We divided these patients into two groups (group 1: Parkinson's disease, group 2: corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy), and compared their clinical characteristics, specific binding ratios, and striatal asymmetry indexes on DAT-SPECT examinations. Results The striatal asymmetry indexes were significantly lower in group 1 than in group 2 (p < 0.05), but there were no differences in the specific binding ratios between the two groups. Conclusion The combined use of striatal asymmetry index on DAT-SPECT and cardiac MIBG scintigraphy might offer useful clues for the differential diagnosis of the early phase Parkinson's disease from other parkinsonian syndromes.
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U2 - 10.1016/j.jns.2017.04.026
DO - 10.1016/j.jns.2017.04.026
M3 - Article
C2 - 28477690
AN - SCOPUS:85017661788
SN - 0022-510X
VL - 377
SP - 174
EP - 178
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -