Usefulness of confocal laser endomicroscopy to diagnose ulcerative colitis-associated neoplasia

Naoki Ohmiya, Noriyuki Horiguchi, Tomomitsu Tahara, Dai Yoshida, Hyuga Yamada, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Makoto Kuroda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chromoendoscopy, narrow-band imaging (NBI), and confocal laser endomicroscopy (CLE) have been introduced in ulcerative colitis (UC)-associated neoplasia surveillance. We aimed to determine the ability of CLE to differentiate among UC-associated neoplasia (differentiated type or undifferentiated type), sporadic adenoma, and circumscribed regenerative lesions. Of 665 patients with UC, we carried out probe-based CLE (pCLE) on 12 patients with suspected UC-associated neoplasia in addition to magnifying chromoendoscopy with crystal violet and NBI. We compared pCLE findings with pathological diagnoses. pCLE could differentiate UC-associated differentiated cancer from other pathologies such as solitary adenoma and non-neoplastic circumscribed regenerative lesions on the basis of back-to-back orientation of crypts (P = 0.048), and UC-associated undifferentiated cancer from other pathologies on the basis of dark trabecular architecture (P = 0.015). Sensitivity, specificity, and accuracy of combination of back-to-back orientation of crypts and dark trabecular architecture for carcinoma or dysplasia were 100%, 83%, and 92%, respectively. In vivo microscopic observation with pCLE was helpful to evaluate the suspected UC-associated neoplasia.

Original languageEnglish
Pages (from-to)626-633
Number of pages8
JournalDigestive Endoscopy
Volume29
Issue number5
DOIs
Publication statusPublished - 01-07-2017

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Ulcerative Colitis
Lasers
Narrow Band Imaging
Neoplasms
Adenoma
Pathology
Gentian Violet
Carcinoma
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Ohmiya, Naoki ; Horiguchi, Noriyuki ; Tahara, Tomomitsu ; Yoshida, Dai ; Yamada, Hyuga ; Nagasaka, Mitsuo ; Nakagawa, Yoshihito ; Shibata, Tomoyuki ; Tsukamoto, Tetsuya ; Kuroda, Makoto. / Usefulness of confocal laser endomicroscopy to diagnose ulcerative colitis-associated neoplasia. In: Digestive Endoscopy. 2017 ; Vol. 29, No. 5. pp. 626-633.
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abstract = "Chromoendoscopy, narrow-band imaging (NBI), and confocal laser endomicroscopy (CLE) have been introduced in ulcerative colitis (UC)-associated neoplasia surveillance. We aimed to determine the ability of CLE to differentiate among UC-associated neoplasia (differentiated type or undifferentiated type), sporadic adenoma, and circumscribed regenerative lesions. Of 665 patients with UC, we carried out probe-based CLE (pCLE) on 12 patients with suspected UC-associated neoplasia in addition to magnifying chromoendoscopy with crystal violet and NBI. We compared pCLE findings with pathological diagnoses. pCLE could differentiate UC-associated differentiated cancer from other pathologies such as solitary adenoma and non-neoplastic circumscribed regenerative lesions on the basis of back-to-back orientation of crypts (P = 0.048), and UC-associated undifferentiated cancer from other pathologies on the basis of dark trabecular architecture (P = 0.015). Sensitivity, specificity, and accuracy of combination of back-to-back orientation of crypts and dark trabecular architecture for carcinoma or dysplasia were 100{\%}, 83{\%}, and 92{\%}, respectively. In vivo microscopic observation with pCLE was helpful to evaluate the suspected UC-associated neoplasia.",
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Ohmiya, N, Horiguchi, N, Tahara, T, Yoshida, D, Yamada, H, Nagasaka, M, Nakagawa, Y, Shibata, T, Tsukamoto, T & Kuroda, M 2017, 'Usefulness of confocal laser endomicroscopy to diagnose ulcerative colitis-associated neoplasia', Digestive Endoscopy, vol. 29, no. 5, pp. 626-633. https://doi.org/10.1111/den.12853

Usefulness of confocal laser endomicroscopy to diagnose ulcerative colitis-associated neoplasia. / Ohmiya, Naoki; Horiguchi, Noriyuki; Tahara, Tomomitsu; Yoshida, Dai; Yamada, Hyuga; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Shibata, Tomoyuki; Tsukamoto, Tetsuya; Kuroda, Makoto.

In: Digestive Endoscopy, Vol. 29, No. 5, 01.07.2017, p. 626-633.

Research output: Contribution to journalArticle

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AU - Ohmiya, Naoki

AU - Horiguchi, Noriyuki

AU - Tahara, Tomomitsu

AU - Yoshida, Dai

AU - Yamada, Hyuga

AU - Nagasaka, Mitsuo

AU - Nakagawa, Yoshihito

AU - Shibata, Tomoyuki

AU - Tsukamoto, Tetsuya

AU - Kuroda, Makoto

PY - 2017/7/1

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