TY - JOUR
T1 - Usefulness of fat-containing agents
T2 - an initial study on estimating fat content for magnetic resonance imaging
AU - Takatsu, Yasuo
AU - Ohnishi, Hiroshi
AU - Tateyama, Tomoko
AU - Miyati, Tosiaki
N1 - Publisher Copyright:
© Australasian College of Physical Scientists and Engineers in Medicine 2024.
PY - 2024/3
Y1 - 2024/3
N2 - This initial study aimed at testing whether fat-containing agents can be used for the fat mass estimation methods using magnetic resonance imaging (MRI). As an example for clinical application, fat-containing agents (based on soybean oil, 10% and 20%), 100% soybean oil, and saline as reference substances were placed outside the proximal femurs obtained from 14 participants and analyzed by 0.3 T MRI. Fat content was the estimated fat fraction (FF) based on signal intensity (SIeFF, %). The SIeFF values of the femoral bone marrow, including the femoral head, neck, shaft, and trochanter area, were measured. MRI data were compared in terms of bone mineral content (BMC) and bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) in the proximal femur. Twelve pig femurs were also used to confirm the correlation between FF by the DIXON method and SIeFF. According to Pearson’s correlation coefficient, the SIeFF and total BMC and BMD data revealed strong and moderate negative correlations in the femoral head (r < − 0.74) and other sites (r = − 0.66 to − 0.45). FF and SIeFF showed a strong correlation (r = 0.96). This study was an initial investigation of a method for estimating fat mass with fat-containing agents and showed the potential for use in MRI. SIeFF and FF showed a strong correlation, and SIeFF and BMD and BMC showed correlation; however, further studies are needed to use SIeFF as a substitute for DXA.
AB - This initial study aimed at testing whether fat-containing agents can be used for the fat mass estimation methods using magnetic resonance imaging (MRI). As an example for clinical application, fat-containing agents (based on soybean oil, 10% and 20%), 100% soybean oil, and saline as reference substances were placed outside the proximal femurs obtained from 14 participants and analyzed by 0.3 T MRI. Fat content was the estimated fat fraction (FF) based on signal intensity (SIeFF, %). The SIeFF values of the femoral bone marrow, including the femoral head, neck, shaft, and trochanter area, were measured. MRI data were compared in terms of bone mineral content (BMC) and bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) in the proximal femur. Twelve pig femurs were also used to confirm the correlation between FF by the DIXON method and SIeFF. According to Pearson’s correlation coefficient, the SIeFF and total BMC and BMD data revealed strong and moderate negative correlations in the femoral head (r < − 0.74) and other sites (r = − 0.66 to − 0.45). FF and SIeFF showed a strong correlation (r = 0.96). This study was an initial investigation of a method for estimating fat mass with fat-containing agents and showed the potential for use in MRI. SIeFF and FF showed a strong correlation, and SIeFF and BMD and BMC showed correlation; however, further studies are needed to use SIeFF as a substitute for DXA.
KW - Bone mineral content
KW - Bone mineral density
KW - Estimated fat fraction based on signal intensity
KW - Fat-containing nutrient solution
KW - Magnetic resonance imaging
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U2 - 10.1007/s13246-023-01372-y
DO - 10.1007/s13246-023-01372-y
M3 - Article
C2 - 38379016
AN - SCOPUS:85185970305
SN - 2662-4729
VL - 47
SP - 339
EP - 350
JO - Physical and Engineering Sciences in Medicine
JF - Physical and Engineering Sciences in Medicine
IS - 1
ER -