Abstract
Of 987 cases of gastric adenocarcinoma seen at Nagoya University School of Medicine, we found 6 rare, extremely well-differentiated advanced gastric adenocarcinomas that could not be diagnosed as malignant tumors with only H & E staining, even with repeated biopsies under preoperative endoscopy. The aim of this study was to determine whether an immunohistochemical method using p53 and Ki-67 antibody would be helpful for preoperative pathologic diagnosis. The cancer control cases were 16 cases of ordinary well-differentiated advanced gastric adenocarcinoma, while the gastritis control cases were 22 cases of Helicobacter pylori-positive chronic gastritis. The p53 labeling index and the localization of Ki-67+ cells showed that the special adenocarcinomas in biopsy specimens were distinct from the surrounding normal mucosa and chronic gastritis, but not from the cancer control cases. These methods are useful markers for preoperative pathologic diagnosis of extremely well-differentiated gastric adenocarcinoma, which sometimes is confused with regenerative atypical glands before operation.
| Original language | English |
|---|---|
| Pages (from-to) | 683-692 |
| Number of pages | 10 |
| Journal | American Journal of Clinical Pathology |
| Volume | 118 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 01-11-2002 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
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Usefulness of p53 and Ki-67 immunohistochemical analysis for preoperative diagnosis of extremely well-differentiated gastric adenocarcinoma. / Niimi, Chikanori; Goto, Hidemi; Ohmiya, Naoki; Niwa, Yasumasa; Hayakawa, Tetsuo; Nagasaka, Tetsuro; Nakashima, Nobuo.
In: American Journal of Clinical Pathology, Vol. 118, No. 5, 01.11.2002, p. 683-692.Research output: Contribution to journal › Article
TY - JOUR
T1 - Usefulness of p53 and Ki-67 immunohistochemical analysis for preoperative diagnosis of extremely well-differentiated gastric adenocarcinoma
AU - Niimi, Chikanori
AU - Goto, Hidemi
AU - Ohmiya, Naoki
AU - Niwa, Yasumasa
AU - Hayakawa, Tetsuo
AU - Nagasaka, Tetsuro
AU - Nakashima, Nobuo
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Of 987 cases of gastric adenocarcinoma seen at Nagoya University School of Medicine, we found 6 rare, extremely well-differentiated advanced gastric adenocarcinomas that could not be diagnosed as malignant tumors with only H & E staining, even with repeated biopsies under preoperative endoscopy. The aim of this study was to determine whether an immunohistochemical method using p53 and Ki-67 antibody would be helpful for preoperative pathologic diagnosis. The cancer control cases were 16 cases of ordinary well-differentiated advanced gastric adenocarcinoma, while the gastritis control cases were 22 cases of Helicobacter pylori-positive chronic gastritis. The p53 labeling index and the localization of Ki-67+ cells showed that the special adenocarcinomas in biopsy specimens were distinct from the surrounding normal mucosa and chronic gastritis, but not from the cancer control cases. These methods are useful markers for preoperative pathologic diagnosis of extremely well-differentiated gastric adenocarcinoma, which sometimes is confused with regenerative atypical glands before operation.
AB - Of 987 cases of gastric adenocarcinoma seen at Nagoya University School of Medicine, we found 6 rare, extremely well-differentiated advanced gastric adenocarcinomas that could not be diagnosed as malignant tumors with only H & E staining, even with repeated biopsies under preoperative endoscopy. The aim of this study was to determine whether an immunohistochemical method using p53 and Ki-67 antibody would be helpful for preoperative pathologic diagnosis. The cancer control cases were 16 cases of ordinary well-differentiated advanced gastric adenocarcinoma, while the gastritis control cases were 22 cases of Helicobacter pylori-positive chronic gastritis. The p53 labeling index and the localization of Ki-67+ cells showed that the special adenocarcinomas in biopsy specimens were distinct from the surrounding normal mucosa and chronic gastritis, but not from the cancer control cases. These methods are useful markers for preoperative pathologic diagnosis of extremely well-differentiated gastric adenocarcinoma, which sometimes is confused with regenerative atypical glands before operation.
UR - http://www.scopus.com/inward/record.url?scp=0036834439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036834439&partnerID=8YFLogxK
U2 - 10.1309/NYA1-V9KQ-NVF8-MA8M
DO - 10.1309/NYA1-V9KQ-NVF8-MA8M
M3 - Article
C2 - 12428787
AN - SCOPUS:0036834439
VL - 118
SP - 683
EP - 692
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 5
ER -