Utility of glucagon stimulation test in type 1 diabetes after pancreas transplantation

I. Hiratsuka, A. Suzuki, M. Kondo-Ando, H. Hirai, Y. Maeda, S. Sekiguchi-Ueda, M. Shibata, T. Takayanagi, M. Makino, N. Fukami, T. Itoh, H. Sasaki, M. Kusaka, T. Kenmochi, K. Hoshinaga, M. Itoh

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Background Despite recent progress of immunosuppressive therapy with newly developed agents, long-term pancreatic graft survival after pancreas transplantation still remains low. Therefore, precise assessment of β-cell function after pancreas transplantation is necessary. Methods Pancreatic β-cell secretory activity was measured by means of the peripheral plasma fasting serum C-peptide (CPR) response to 1 mg of glucagon intravenously in 23 patients after pancreas transplantation. The utility of ΔCPR after injection was compared with other indices that reflect insulin secretion. Results When we performed the test, 6 patients still needed insulin injection after the transplantation. Mean CPR before and after glucagon intravenously were 1.9 ± 0.98 ng/mL and 4.6 ± 2.29 ng/mL, respectively. Fasting serum CPR, secretory unit of islet in transplantation (SUIT) index, and ΔCPR after glucagon injection were significantly different between insulin users and nonusers. During follow-up (501 ± 228 days), 3 patients could stop using insulin, and their increase of CPR (1.8 ± 0.5 ng/mL) was significantly higher than that in continuous insulin users (0.3 ± 0.3 ng/mL). Conclusion Fasting CPR, SUIT index, and ΔCPR after glucagon injection could reflect β-cell function for post-pancreas transplant patients, and glucagon stimulation test could give us additional information to predict insulin-free treatment.

Original languageEnglish
Pages (from-to)967-969
Number of pages3
JournalTransplantation Proceedings
Issue number3
Publication statusPublished - 01-01-2014

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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    Hiratsuka, I., Suzuki, A., Kondo-Ando, M., Hirai, H., Maeda, Y., Sekiguchi-Ueda, S., Shibata, M., Takayanagi, T., Makino, M., Fukami, N., Itoh, T., Sasaki, H., Kusaka, M., Kenmochi, T., Hoshinaga, K., & Itoh, M. (2014). Utility of glucagon stimulation test in type 1 diabetes after pancreas transplantation. Transplantation Proceedings, 46(3), 967-969. https://doi.org/10.1016/j.transproceed.2013.11.027