Utility of intraoperative real-time near-infrared fluorescence surgery for spinal schwannoma

Jun Muto, Yutaka Mine, Sota Nagai, Naoyuki Shizu, Hiroki Takeda, Daiki Ikeda, Akifumi Saito, Masahiro Joko, Mitsuhiro Hasegawa, Shinjiro Kaneko, Tatsushi Inoue, John Y.K. Lee, Yuichi Hirose

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The authors report the first cases of fluorescence-guided spinal surgery of schwannomas using near-infrared fluorescence imaging with the delayed window indocyanine (ICG) green (DWIG) technique for accurate real-time intraoperative tumor visualization. Patients with intradural spinal schwannomas received 0.5 mg/kg ICG at the beginning of surgery. After 1 hour, using the DWIG technique, near-infrared spectroscopy (NIRS) detected the spinal schwannomas, showing the exact tumor location and boundaries. DWIG with NIRS microscopy confirmed the exact location of spinal schwannomas before and after opening of the dura mater, thereby facilitating successful tumor dissection from the surrounding tissues, tumor resection, and confirmation of tumor removal.

Original languageEnglish
JournalNeurosurgical Focus: Video
Issue number1
Publication statusPublished - 01-2022

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology


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