Utility of intraoperative real-time near-infrared fluorescence surgery for spinal schwannoma

Jun Muto; Yutaka Mine; Sota Nagai; Naoyuki Shizu; Hiroki Takeda; Daiki Ikeda; Akifumi Saito; Masahiro Joko; Mitsuhiro Hasegawa; Shinjiro Kaneko; Tatsushi Inoue; John Y.K. Lee; Yuichi Hirose

doi:10.3171/2021.10.FOCVID21158

Utility of intraoperative real-time near-infrared fluorescence surgery for spinal schwannoma

Jun Muto, Yutaka Mine, Sota Nagai, Naoyuki Shizu, Hiroki Takeda, Daiki Ikeda, Akifumi Saito, Masahiro Joko, Mitsuhiro Hasegawa, Shinjiro Kaneko, Tatsushi Inoue, John Y.K. Lee, Yuichi Hirose

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The authors report the first cases of fluorescence-guided spinal surgery of schwannomas using near-infrared fluorescence imaging with the delayed window indocyanine (ICG) green (DWIG) technique for accurate real-time intraoperative tumor visualization. Patients with intradural spinal schwannomas received 0.5 mg/kg ICG at the beginning of surgery. After 1 hour, using the DWIG technique, near-infrared spectroscopy (NIRS) detected the spinal schwannomas, showing the exact tumor location and boundaries. DWIG with NIRS microscopy confirmed the exact location of spinal schwannomas before and after opening of the dura mater, thereby facilitating successful tumor dissection from the surrounding tissues, tumor resection, and confirmation of tumor removal.

Original language	English
Journal	Neurosurgical Focus: Video
Volume	6
Issue number	1
DOIs	https://doi.org/10.3171/2021.10.FOCVID21158
Publication status	Published - 01-2022

All Science Journal Classification (ASJC) codes

Surgery
Neurology

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title = "Utility of intraoperative real-time near-infrared fluorescence surgery for spinal schwannoma",

abstract = "The authors report the first cases of fluorescence-guided spinal surgery of schwannomas using near-infrared fluorescence imaging with the delayed window indocyanine (ICG) green (DWIG) technique for accurate real-time intraoperative tumor visualization. Patients with intradural spinal schwannomas received 0.5 mg/kg ICG at the beginning of surgery. After 1 hour, using the DWIG technique, near-infrared spectroscopy (NIRS) detected the spinal schwannomas, showing the exact tumor location and boundaries. DWIG with NIRS microscopy confirmed the exact location of spinal schwannomas before and after opening of the dura mater, thereby facilitating successful tumor dissection from the surrounding tissues, tumor resection, and confirmation of tumor removal.",

author = "Jun Muto and Yutaka Mine and Sota Nagai and Naoyuki Shizu and Hiroki Takeda and Daiki Ikeda and Akifumi Saito and Masahiro Joko and Mitsuhiro Hasegawa and Shinjiro Kaneko and Tatsushi Inoue and Lee, {John Y.K.} and Yuichi Hirose",

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doi = "10.3171/2021.10.FOCVID21158",

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T1 - Utility of intraoperative real-time near-infrared fluorescence surgery for spinal schwannoma

AU - Muto, Jun

AU - Mine, Yutaka

AU - Nagai, Sota

AU - Shizu, Naoyuki

AU - Takeda, Hiroki

AU - Ikeda, Daiki

AU - Saito, Akifumi

AU - Joko, Masahiro

AU - Hasegawa, Mitsuhiro

AU - Kaneko, Shinjiro

AU - Inoue, Tatsushi

AU - Lee, John Y.K.

AU - Hirose, Yuichi

PY - 2022/1

Y1 - 2022/1

N2 - The authors report the first cases of fluorescence-guided spinal surgery of schwannomas using near-infrared fluorescence imaging with the delayed window indocyanine (ICG) green (DWIG) technique for accurate real-time intraoperative tumor visualization. Patients with intradural spinal schwannomas received 0.5 mg/kg ICG at the beginning of surgery. After 1 hour, using the DWIG technique, near-infrared spectroscopy (NIRS) detected the spinal schwannomas, showing the exact tumor location and boundaries. DWIG with NIRS microscopy confirmed the exact location of spinal schwannomas before and after opening of the dura mater, thereby facilitating successful tumor dissection from the surrounding tissues, tumor resection, and confirmation of tumor removal.

AB - The authors report the first cases of fluorescence-guided spinal surgery of schwannomas using near-infrared fluorescence imaging with the delayed window indocyanine (ICG) green (DWIG) technique for accurate real-time intraoperative tumor visualization. Patients with intradural spinal schwannomas received 0.5 mg/kg ICG at the beginning of surgery. After 1 hour, using the DWIG technique, near-infrared spectroscopy (NIRS) detected the spinal schwannomas, showing the exact tumor location and boundaries. DWIG with NIRS microscopy confirmed the exact location of spinal schwannomas before and after opening of the dura mater, thereby facilitating successful tumor dissection from the surrounding tissues, tumor resection, and confirmation of tumor removal.

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Utility of intraoperative real-time near-infrared fluorescence surgery for spinal schwannoma

Abstract

All Science Journal Classification (ASJC) codes

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